Journal article
Endemic fungal infections in solid organ and hematopoietic cell transplant recipients enrolled in the Transplant‐Associated Infection Surveillance Network (TRANSNET)
Transplant infectious disease, Vol.16(2), pp.213-224
04/2014
DOI: 10.1111/tid.12186
PMCID: PMC5664161
PMID: 24589027
Abstract
Background
Invasive fungal infections are a major cause of morbidity and mortality among solid organ transplant (SOT) and hematopoietic cell transplant (HCT) recipients, but few data have been reported on the epidemiology of endemic fungal infections in these populations.
Methods
Fifteen institutions belonging to the Transplant‐Associated Infection Surveillance Network prospectively enrolled SOT and HCT recipients with histoplasmosis, blastomycosis, or coccidioidomycosis occurring between March 2001 and March 2006.
Results
A total of 70 patients (64 SOT recipients and 6 HCT recipients) had infection with an endemic mycosis, including 52 with histoplasmosis, 9 with blastomycosis, and 9 with coccidioidomycosis. The 12‐month cumulative incidence rate among SOT recipients for histoplasmosis was 0.102%. Occurrence of infection was bimodal; 28 (40%) infections occurred in the first 6 months post transplantation, and 24 (34%) occurred between 2 and 11 years post transplantation. Three patients were documented to have acquired infection from the donor organ. Seven SOT recipients with histoplasmosis and 3 with coccidioidomycosis died (16%); no HCT recipient died.
Conclusions
This 5‐year multicenter prospective surveillance study found that endemic mycoses occur uncommonly in SOT and HCT recipients, and that the period at risk extends for years after transplantation.
Details
- Title: Subtitle
- Endemic fungal infections in solid organ and hematopoietic cell transplant recipients enrolled in the Transplant‐Associated Infection Surveillance Network (TRANSNET)
- Creators
- L Herwaldt - University of Iowa Carver College of Medicine and University of Iowa Hospital and ClinicsC.A Kauffman - University of Michigan and Veterans Affairs Ann Arbor Healthcare SystemA.G Freifeld - University of Nebraska Medical CenterB.D Alexander - Duke University Medical CenterD.R Andes - University of WisconsinJ.W Baddley - University of Alabama at Birmingham Medical Center and Veterans Affairs Medical CenterR.C Walker - Mayo ClinicE.J Anaissie - University of Arkansas for Medical SciencesK Benedict - Centers for Disease Control and PreventionJ.I Ito - City of Hope Comprehensive Cancer CenterK.M Knapp - St. Jude Children's Research HospitalG.M Lyon - Emory University School of MedicineK.A Marr - Fred Hutchinson Cancer Research CenterV.A Morrison - University of Minnesota and Veterans Affairs Medical CenterB.J Park - Centers for Disease Control and PreventionT.F Patterson - University of Texas Health Sciences Center and South Texas Veterans Healthcare SystemM.G Schuster - Perelman School of Medicine at the University of PennsylvaniaT.M Chiller - Centers for Disease Control and PreventionP.G Pappas - University of Alabama at Birmingham Medical Center and Veterans Affairs Medical Center
- Resource Type
- Journal article
- Publication Details
- Transplant infectious disease, Vol.16(2), pp.213-224
- DOI
- 10.1111/tid.12186
- PMID
- 24589027
- PMCID
- PMC5664161
- ISSN
- 1398-2273
- eISSN
- 1399-3062
- Number of pages
- 12
- Grant note
- Schering‐Plough Research Institute Merck & Co., Inc. Astellas US, Inc. CDC (5U01CI000286‐05) Enzon Pharmaceuticals, Inc Pfizer, Inc.
- Language
- English
- Date published
- 04/2014
- Academic Unit
- Infectious Diseases; Epidemiology; Internal Medicine
- Record Identifier
- 9984094361302771
Metrics
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