Journal article
Endocannabinoid Receptor-1 and Sympathetic Nervous System Mediate the Beneficial Metabolic Effects of Gastric Bypass
Cell reports (Cambridge), Vol.33(4), pp.108270-108270
10/27/2020
DOI: 10.1016/j.celrep.2020.108270
PMID: 33113371
Abstract
The exact mechanisms underlying the metabolic effects of bariatric surgery remain unclear. Here, we demonstrate, using a combination of direct and indirect calorimetry, an increase in total resting metabolic rate (RMR) and specifically anaerobic RMR after Roux-en-Y gastric bypass (RYGB), but not sleeve gastrectomy (SG). We also show an RYGB-specific increase in splanchnic sympathetic nerve activity and “browning” of visceral mesenteric fat. Consequently, selective splanchnic denervation abolishes all beneficial metabolic outcomes of gastric bypass that involve changes in the endocannabinoid signaling within the small intestine. Furthermore, we demonstrate that administration of rimonabant, an endocannabinoid receptor-1 (CB1) inverse agonist, to obese mice mimics RYGB-specific effects on energy balance and splanchnic nerve activity. On the other hand, arachidonoylethanolamide (AEA), a CB1 agonist, attenuates the weight loss and metabolic signature of this procedure. These findings identify CB1 as a key player in energy regulation post-RYGB via a pathway involving the sympathetic nervous system.
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•RYGB, but not SG, increases energy expenditure (EE) and RMR•This increase in EE is due to sympathetic-mediated “browning” of mesenteric fat•CB1 inverse agonist induces splanchnic nerve activity and fat thermogenesis•CB1 agonist attenuates the RYGB-induced weight loss and “browning” of mesenteric fat
Ye et al. show that energy regulation differs between Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) where only RYGB enhances splanchnic nerve activity, to induce visceral fat thermogenesis, and increases resting metabolic rate (RMR). This sympathetic-mediated “browning” of visceral fat seems to be dependent on endocannabinoid receptor-1 (CB1) signaling.
Details
- Title: Subtitle
- Endocannabinoid Receptor-1 and Sympathetic Nervous System Mediate the Beneficial Metabolic Effects of Gastric Bypass
- Creators
- Yuanchao Ye - Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USAMarwa Abu El Haija - Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Stanford University School of Medicine, Palo Alto, CA 94304, USADonald A Morgan - Department of Neuroscience and Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USADeng Guo - Department of Neuroscience and Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USAYang Song - College of Pharmacy, China Medical University, 77 Puhe Rd., Liaoning 110122, P.R. ChinaAaron Frank - The Biomedical Research Department, Diabetes and Obesity Research Division, Cedars Sinai Medical Center, Beverly Hills, CA 90048, USALiping Tian - Department of Clinical Pharmacy, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu 211198, P.R. ChinaRuth A Riedl - Department of Neuroscience and Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USAColin M.L Burnett - Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USAZhan Gao - Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USAZhiyong Zhu - Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USAShailesh K Shahi - Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USAKasra Zarei - Medical Scientist Training Program, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USAAnne Couvelard - INSERM U1149, Centre de Recherche sur l’Inflammation, Université de Paris, Paris 75018, FranceNicolas Poté - INSERM U1149, Centre de Recherche sur l’Inflammation, Université de Paris, Paris 75018, FranceLara Ribeiro-Parenti - INSERM U1149, Centre de Recherche sur l’Inflammation, Université de Paris, Paris 75018, FranceAndré Bado - INSERM U1149, Centre de Recherche sur l’Inflammation, Université de Paris, Paris 75018, FranceLama Noureddine - Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USAAndrew Bellizzi - Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USAPaul Kievit - Division of Diabetes, Obesity and Metabolism, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USAAshutosh K Mangalam - Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USALeonid V Zingman - Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USAMaude Le Gall - INSERM U1149, Centre de Recherche sur l’Inflammation, Université de Paris, Paris 75018, FranceJustin L Grobe - Departments of Physiology and Biomedical Engineering, Medical College of Wisconsin, Milwaukee, MI 53226, USALee M Kaplan - Department of Medicine, Harvard Medical School, Boston, MA 02115, USADeborah Clegg - College of Nursing and Health Professions, Drexel University, 1601 Cherry Street, Philadelphia, PA 19102, USAKamal Rahmouni - Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USAMohamad Mokadem - Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- Cell reports (Cambridge), Vol.33(4), pp.108270-108270
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.celrep.2020.108270
- PMID
- 33113371
- ISSN
- 2211-1247
- eISSN
- 2211-1247
- Grant note
- DOI: 10.13039/100009560, name: American Gastroenterological Association; DOI: 10.13039/100000968, name: American Heart Association; DOI: 10.13039/100000002, name: National Institutes of Health; DOI: 10.13039/100000738, name: U.S. Department of Veterans Affairs
- Language
- English
- Date published
- 10/27/2020
- Academic Unit
- Gastroenterology and Hepatology; Pathology; Iowa Neuroscience Institute; Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology; Nephrology; Internal Medicine
- Record Identifier
- 9984070558102771
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