Journal article
Endocannabinoids and Dopamine Balance Basal Ganglia Output
Frontiers in cellular neuroscience, Vol.15, pp.639082-639082
03/17/2021
DOI: 10.3389/fncel.2021.639082
PMCID: 8010132
PMID: 33815062
Abstract
The entopeduncular nucleus is one of the basal ganglia's output nuclei, thereby controlling basal ganglia information processing. Entopeduncular nucleus neurons integrate GABAergic inputs from the Striatum and the globus pallidus, together with glutamatergic inputs from the subthalamic nucleus. We show that endocannabinoids and dopamine interact to modulate the long-term plasticity of all these primary afferents to the entopeduncular nucleus. Our results suggest that the interplay between dopamine and endocannabinoids determines the balance between direct pathway (striatum) and indirect pathway (globus pallidus) in entopeduncular nucleus output. Furthermore, we demonstrate that, despite the lack of axon collaterals, information is transferred between neighboring neurons in the entopeduncular nucleus via endocannabinoid diffusion. These results transform the prevailing view of the entopeduncular nucleus as a feedforward "relay" nucleus to an intricate control unit, which may play a vital role in the process of action selection.
Details
- Title: Subtitle
- Endocannabinoids and Dopamine Balance Basal Ganglia Output
- Creators
- Lilach Gorodetski - Bar-Ilan UniversityYocheved Loewenstern - Bar-Ilan UniversityAnna Faynveitz - Bar-Ilan UniversityIzhar Bar-Gad - Bar-Ilan UniversityKim T. Blackwell - George Mason UniversityAlon Korngreen - Bar-Ilan University
- Resource Type
- Journal article
- Publication Details
- Frontiers in cellular neuroscience, Vol.15, pp.639082-639082
- DOI
- 10.3389/fncel.2021.639082
- PMID
- 33815062
- PMCID
- 8010132
- NLM abbreviation
- Front Cell Neurosci
- ISSN
- 1662-5102
- eISSN
- 1662-5102
- Publisher
- Frontiers Media Sa
- Number of pages
- 17
- Grant note
- 225/20; 297/18 / Israel Science Foundation R01AA16022 / National Institute on Alcohol Abuse and Alcoholism; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Alcohol Abuse & Alcoholism (NIAAA) R01DA033390 / National Institute on Drug Abuse; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA)
- Language
- English
- Date published
- 03/17/2021
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Iowa Neuroscience Institute
- Record Identifier
- 9984446277302771
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