Journal article
Endocervical Prostaglandin-E2 Gel for Preinduction Cervical Softening
Prostaglandins, Vol.27(3), pp.429-439
01/01/1984
DOI: 10.1016/0090-6980(84)90201-6
PMID: 06374766
Abstract
A single, endocervical application of a new commercial preparation of prostaglandin E2 (PGE2) gel, 0.5 mg of PGE2 in 2.5 ml (3 g), was evaluated for preinduction cervical softening. Safety and efficacy were assessed in a comparison with a 2.0 mg PGE2 vaginal tablet and placebo in normal nulliparous women at term, with low Bishop scores. Treatment was administered in randomized, double blind fashion. Overall success, defined as a progression in Bishop score of at least 3 points within 12 hours, was achieved in 22/40 (55%) of the gel group, 15/41 (37%) in the tablet treated women, and 8/40 (20%) in those receiving placebo. Of interest was the observation that of women with very unfavorable induction features (Bishop score 0-2), the cervical gel treatment resulted in a 6/8 (75%) success rate compared with 2/13 (15%) success for the vaginal tablet and 0/17 (0%) for placebo. In as much as a very low incidence of side effects accompanied this treatment scheme, expanded multi-center testing is recommended.
Details
- Title: Subtitle
- Endocervical Prostaglandin-E2 Gel for Preinduction Cervical Softening
- Creators
- M. ThieryJ. M. DecosterW. ParewijckM. L. NoahR. DeromH. VanketsP. DefoortW. AertsensG. DebruyneKoen De Geest - University of IowaF. Vandekerckhove
- Resource Type
- Journal article
- Publication Details
- Prostaglandins, Vol.27(3), pp.429-439
- DOI
- 10.1016/0090-6980(84)90201-6
- PMID
- 06374766
- ISSN
- 0090-6980
- Language
- English
- Date published
- 01/01/1984
- Academic Unit
- Obstetrics and Gynecology
- Record Identifier
- 9983557117602771
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