Journal article
Endocrine fibroblast growth factors 15/19 and 21: from feast to famine
Genes & development, Vol.26(4), pp.312-324
02/15/2012
DOI: 10.1101/gad.184788.111
PMCID: PMC3289879
PMID: 22302876
Abstract
We review the physiology and pharmacology of two atypical fibroblast growth factors (FGFs)-FGF15/19 and FGF21-that can function as hormones. Both FGF15/19 and FGF21 act on multiple tissues to coordinate carbohydrate and lipid metabolism in response to nutritional status. Whereas FGF15/19 is secreted from the small intestine in response to feeding and has insulin-like actions, FGF21 is secreted from the liver in response to extended fasting and has glucagon-like effects. FGF21 also acts in an autocrine fashion in several tissues, including adipose. The pharmacological actions of FGF15/19 and FGF21 make them attractive drug candidates for treating metabolic disease.
Details
- Title: Subtitle
- Endocrine fibroblast growth factors 15/19 and 21: from feast to famine
- Creators
- Matthew J Potthoff - Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, 75390, USASteven A KliewerDavid J Mangelsdorf
- Resource Type
- Journal article
- Publication Details
- Genes & development, Vol.26(4), pp.312-324
- Publisher
- United States
- DOI
- 10.1101/gad.184788.111
- PMID
- 22302876
- PMCID
- PMC3289879
- ISSN
- 0890-9369
- eISSN
- 1549-5477
- Grant note
- RL1 GM084436 / NIGMS NIH HHS RL1GM084436 / NIGMS NIH HHS R01 DK067158 / NIDDK NIH HHS 5R01DK067158 / NIDDK NIH HHS Howard Hughes Medical Institute
- Language
- English
- Date published
- 02/15/2012
- Academic Unit
- Iowa Neuroscience Institute; Neuroscience and Pharmacology
- Record Identifier
- 9984040265402771
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