Journal article
Endogenous Dopamine Competes with the Binding of a Radiolabeled D3 Receptor Partial Agonist In Vivo: A Positron Emission Tomography Study
Synapse (New York, N.Y.), Vol.65(8), pp.724-732
08/2011
DOI: 10.1002/syn.20891
PMCID: PMC3107898
PMID: 21132811
Abstract
A series of microPET imaging studies were conducted in anesthetized rhesus monkeys using the dopamine D
3
-selective partial agonist, [
18
F]
5
. There was variable uptake in regions of brain known to express a high density of D
3
receptors under baseline conditions. Pretreatment with lorazepam (1 mg/kg, i.v. 30 min) to reduce endogenous dopamine activity prior to tracer injection resulted in a dramatic increase in uptake in the caudate, putamen, and thalamus, and an increase in the binding potential (BP) values, a measure of D
3
receptor binding in vivo. These data indicate that there is a high level of competition between [
18
F]
5
and endogenous dopamine for D
3
receptors in vivo.
Details
- Title: Subtitle
- Endogenous Dopamine Competes with the Binding of a Radiolabeled D3 Receptor Partial Agonist In Vivo: A Positron Emission Tomography Study
- Creators
- Robert H Mach - Division of Radiological Sciences, Washington University School of Medicine, Mallinckrodt Institute of Radiology, 510 S. Kingshighway, St. Louis, MO 63110Zhude Tu - Division of Radiological Sciences, Washington University School of Medicine, Mallinckrodt Institute of Radiology, 510 S. Kingshighway, St. Louis, MO 63110Jinbin Xu - Division of Radiological Sciences, Washington University School of Medicine, Mallinckrodt Institute of Radiology, 510 S. Kingshighway, St. Louis, MO 63110Shihong Li - Division of Radiological Sciences, Washington University School of Medicine, Mallinckrodt Institute of Radiology, 510 S. Kingshighway, St. Louis, MO 63110Lynne A Jones - Division of Radiological Sciences, Washington University School of Medicine, Mallinckrodt Institute of Radiology, 510 S. Kingshighway, St. Louis, MO 63110Michelle Taylor - Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, Texas 76107Robert R Luedtke - Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, Texas 76107Colin P Derdeyn - Division of Radiological Sciences, Washington University School of Medicine, Mallinckrodt Institute of Radiology, 510 S. Kingshighway, St. Louis, MO 63110Joel S Perlmutter - Division of Radiological Sciences, Washington University School of Medicine, Mallinckrodt Institute of Radiology, 510 S. Kingshighway, St. Louis, MO 63110Mark A Mintun - Division of Radiological Sciences, Washington University School of Medicine, Mallinckrodt Institute of Radiology, 510 S. Kingshighway, St. Louis, MO 63110
- Resource Type
- Journal article
- Publication Details
- Synapse (New York, N.Y.), Vol.65(8), pp.724-732
- DOI
- 10.1002/syn.20891
- PMID
- 21132811
- PMCID
- PMC3107898
- NLM abbreviation
- Synapse
- ISSN
- 0887-4476
- eISSN
- 1098-2396
- Language
- English
- Date published
- 08/2011
- Academic Unit
- Neurology; Radiology; Iowa Neuroscience Institute; Neurosurgery
- Record Identifier
- 9984020643602771
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