Journal article
Endogenous sex hormones and breast density in young women
Cancer epidemiology, biomarkers & prevention, Vol.24(2), pp.369-378
02/2015
DOI: 10.1158/1055-9965.EPI-14-0939
PMCID: PMC4323882
PMID: 25371447
Abstract
Breast density is a strong risk factor for breast cancer and reflects epithelial and stromal content. Breast tissue is particularly sensitive to hormonal stimuli before it fully differentiates following the first full-term pregnancy. Few studies have examined associations between sex hormones and breast density among young women.
We conducted a cross-sectional study among 180 women ages 25 to 29 years old who participated in the Dietary Intervention Study in Children 2006 Follow-up Study. Eighty-five percent of participants attended a clinic visit during their luteal phase of menstrual cycle. Magnetic resonance imaging measured the percentage of dense breast volume (%DBV), absolute dense breast volume (ADBV), and absolute nondense breast volume (ANDBV). Multiple-linear mixed-effect regression models were used to evaluate the association of sex hormones and sex hormone-binding globulin (SHBG) with %DBV, ADBV, and ANDBV.
Testosterone was significantly positively associated with %DBV and ADBV. The multivariable geometric mean of %DBV and ADBV across testosterone quartiles increased from 16.5% to 20.3% and from 68.6 to 82.3 cm(3), respectively (Ptrend ≤ 0.03). There was no association of %DBV or ADBV with estrogens, progesterone, non-SHBG-bound testosterone, or SHBG (Ptrend ≥ 0.27). Neither sex hormones nor SHBG was associated with ANDBV except progesterone; however, the progesterone result was nonsignificant in analysis restricted to women in the luteal phase.
These findings suggest a modest positive association between testosterone and breast density in young women.
Hormonal influences at critical periods may contribute to morphologic differences in the breast associated with breast cancer risk later in life.
Details
- Title: Subtitle
- Endogenous sex hormones and breast density in young women
- Creators
- Seungyoun Jung - University of Maryland School of Medicine, Baltimore, MarylandFrank Z Stanczyk - University of Southern California Keck School of Medicine, Los Angeles, CaliforniaBrian L Egleston - Fox Chase Cancer Center, Philadelphia, PennsylvaniaLinda G Snetselaar - University of Iowa, Iowa City, IowaVictor J Stevens - Kaiser Permanente Center for Health Research, Portland, OregonJohn A Shepherd - University of California San Francisco, San Francisco, CaliforniaLinda Van Horn - Feinberg School of Medicine, Northwestern University, Chicago, IllinoisErin S LeBlanc - Kaiser Permanente Center for Health Research, Portland, OregonKenneth Paris - Louisiana State University School of Medicine, New Orleans, LouisianaCatherine Klifa - Dangeard Group, San Francisco, CaliforniaJoanne F Dorgan - University of Maryland School of Medicine, Baltimore, Maryland. jdorgan@som.umaryland.edu
- Resource Type
- Journal article
- Publication Details
- Cancer epidemiology, biomarkers & prevention, Vol.24(2), pp.369-378
- Publisher
- United States
- DOI
- 10.1158/1055-9965.EPI-14-0939
- PMID
- 25371447
- PMCID
- PMC4323882
- ISSN
- 1055-9965
- eISSN
- 1538-7755
- Grant note
- R01 CA104670 / NCI NIH HHS R03 CA167764 / NCI NIH HHS
- Language
- English
- Date published
- 02/2015
- Academic Unit
- Epidemiology; Internal Medicine
- Record Identifier
- 9983996075302771
Metrics
13 Record Views