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Endometrial Cancer: Obesity, Genetics, and Targeted Agents
Journal article   Peer reviewed

Endometrial Cancer: Obesity, Genetics, and Targeted Agents

Megan E McDonald and David P Bender
Obstetrics and gynecology clinics of North America, Vol.46(1), pp.89-105
03/2019
DOI: 10.1016/j.ogc.2018.09.006
PMID: 30683268

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Abstract

It is imperative to understand the underlying mechanisms of both endometrial carcinogenesis and recurrence in order to develop more effective prevention and treatment. This article reviews available molecular data, the interplay between endometrial cancer carcinogenesis with obesity and genetics, as well as current targeted therapies.
Age Factors Obesity - complications Humans Molecular Targeted Therapy Biomarkers, Tumor Randomized Controlled Trials as Topic Progesterone - therapeutic use Endometrial Neoplasms - genetics Antineoplastic Agents, Hormonal - therapeutic use Endometrial Neoplasms - complications Endometrial Neoplasms - drug therapy Endometrial Neoplasms - pathology Female

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