Journal article
Endometriosis and Assisted Reproductive Technology: United States Trends and Outcomes 2000–2011
Fertility and sterility, Vol.103(6), pp.1537-1543
06/01/2015
DOI: 10.1016/j.fertnstert.2015.03.003
PMCID: PMC11057003
PMID: 25881877
Abstract
To assess endometriosis-associated infertility trends among assisted reproductive technology (ART) cycles, and to compare cancellation and hyperstimulation risks and pregnancy and live birth rates among women using ART for endometriosis-associated vs. male factor infertility.
Descriptive and multivariable analyses of Centers for Disease Control and Prevention (CDC) National ART Surveillance System data.
Fertility centers.
All reported fresh autologous ART cycles in the United States between 2000 and 2011 (n = 1,589,079).
None.
Oocyte yield, hyperstimulation, cancellation, implantation, pregnancy, live birth.
The absolute number of ART cycles with an endometriosis diagnosis fell in recent years, from 16,751 (2000) to 15,311 (2011); the percentage fell over time, from 17.0% (2000) to 9.6% (2011) of all cycles. Compared with male factor (n = 375,557), endometriosis-associated cycles (n = 112,475) yielded fewer oocytes (50.5% vs. 42.5% of cycles with only 0–10 oocytes retrieved), lower risk of hyperstimulation (1.1% vs. 1.3%, adjusted risk ratio [aRR] 0.82, 95% confidence interval [CI] 0.74–0.91), and an increased risk of cancellation (12.9% vs. 10.1%, aRR 1.30, 95% CI 1.25–1.35). Endometriosis was associated with a statistically decreased but likely clinically insignificant difference in the following outcomes: chance of pregnancy per transfer (43.7% vs. 44.8%, aRR 0.96, 95% CI 0.95–0.98) among couples who did not also have tubal factor infertility and live birth per transfer (37.2% vs. 37.6%, aRR 0.96, 95% CI 0.94–0.98).
The percentage of endometriosis-associated ART cycles has decreased over time. As compared with male factor infertility, endometriosis is associated with increased cancellation and decreased hyperstimulation risks. Despite decreased oocyte yield and higher medication dose, the difference in pregnancy and live birth rates may be of limited clinical significance, suggesting comparable pregnancy outcomes per transfer.
Details
- Title: Subtitle
- Endometriosis and Assisted Reproductive Technology: United States Trends and Outcomes 2000–2011
- Creators
- Jennifer F. Kawwass - Emory UniversitySara Crawford - National Center for Chronic Disease Prevention and Health PromotionDonna R. Session - Emory UniversityDmitry M. Kissin - Emory UniversityDenise J. Jamieson - Emory UniversityNational ART Surveillance System Group
- Resource Type
- Journal article
- Publication Details
- Fertility and sterility, Vol.103(6), pp.1537-1543
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.fertnstert.2015.03.003
- PMID
- 25881877
- PMCID
- PMC11057003
- ISSN
- 0015-0282
- eISSN
- 1556-5653
- Language
- English
- Date published
- 06/01/2015
- Academic Unit
- Obstetrics and Gynecology; VPMA - Administration
- Record Identifier
- 9984446402102771
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