Journal article
Endoscopic findings and esophageal cancer incidence among Fanconi Anemia patients participating in an endoscopic surveillance program
Digestive and liver disease, Vol.51(2), pp.242-246
02/2019
DOI: 10.1016/j.dld.2018.08.010
PMID: 30249500
Abstract
The primary clinical characteristics of Fanconi Anemia (FA) include typical physical features, progressive bone marrow failure, and an increased incidence of neoplasms, including esophageal carcinoma. Currently, there are no data regarding endoscopic findings or the interval time to malignancy in these patients. Data about the contribution of Human Papilloma Virus (HPV) to esophageal carcinoma is conflicting. Our objective is to document the upper gastrointestinal (GI) findings at baseline, document cancer incidence, and evaluate the role of HPV among these cancers.
We reviewed endoscopic and clinical data of FA subjects who participated in active surveillance before cancer diagnosis. Incident esophageal cancers were stained for HPV
protein.
Eight FA patients were included (men 62.5%; median age at first endoscopy 20 years, median endoscopies number: 5.5). At baseline, 8/8 had endoscopic evidence for reflux esophagitis. In 3/8 the reflux esophagitis was mild and in 5/8 it was moderate or severe. During the follow up time (median time 4.5 years 2/8 developed Barrett's esophagus and 2/8 patients had incident esophageal squamous cell carcinoma during follow up, at intervals of eight and eighteen months from the previous upper endoscopy. Both cancers stained negative for HPV
.
FA subjects have both an extremely high risk for esophageal cancer within short intervals and a very high prevalence of reflux esophagitis with various severities. Active surveillance programs in specialized centers including annual upper endoscopies should be considered in these patients.
Details
- Title: Subtitle
- Endoscopic findings and esophageal cancer incidence among Fanconi Anemia patients participating in an endoscopic surveillance program
- Creators
- David Itskoviz - Rabin Medical CenterHannah Tamary - Rabin Medical CenterTanya Krasnov - Tel Aviv UniversityJoannae Yacobovich - Tel Aviv UniversityNadav Sahar - Rabin Medical CenterNoam Zevit - Schneider Children's Medical CenterRaanan Shamir - Schneider Children's Medical CenterOffer Ben-Bassat - Rabin Medical CenterYaara Leibovici WisemanRam Dickman - Rabin Medical CenterYehuda Ringel - Rabin Medical CenterIris Dotan - Rabin Medical CenterYael Goldberg - Rabin Medical CenterSara Morgenstern - Rabin Medical CenterZohar Levi - Rabin Medical Center
- Resource Type
- Journal article
- Publication Details
- Digestive and liver disease, Vol.51(2), pp.242-246
- DOI
- 10.1016/j.dld.2018.08.010
- PMID
- 30249500
- ISSN
- 1590-8658
- eISSN
- 1878-3562
- Language
- English
- Date published
- 02/2019
- Academic Unit
- Gastroenterology and Hepatology; Internal Medicine
- Record Identifier
- 9984359813402771
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