Journal article
Endoscopic ultrasound and computer tomography are inaccurate methods of classifying cystic pancreatic lesions
Digestive and liver disease, Vol.38(1), pp.39-44
2006
DOI: 10.1016/j.dld.2005.09.023
PMID: 16314152
Abstract
Despite advances in imaging modalities, preoperative diagnosis of pancreatic cystic lesions remains difficult.
To assess the accuracy of endoscopic ultrasound and computer tomography to preoperatively distinguish benign from potentially malignant and malignant pancreatic cystic lesions.
Photograph series obtained from endoscopic ultrasound examinations of 66 patients with cystic pancreatic lesions were blindly reviewed by three endoscopic ultrasonographers. Forty-one of those 66 patients also underwent a computer tomography scan at our institution, which was blindly reviewed by a single radiologist. Computer tomography and endoscopic ultrasound classification into benign and malignant and potentially malignant pancreatic cystic lesions was correlated with the final diagnosis, which was established by surgical pathology (
n
=
43), diagnostic fine needle aspiration (
n
=
13) or follow-up imaging (
n
=
10). Interobserver agreement was measured using kappa statistics.
Endoscopic ultrasound classification by the three examiners into benign versus malignant or potentially malignant cystic lesions was correct in 65–67%. Interobserver agreement was 50%. Kappa values for pairs of endoscopic ultrasound examiners were 0.16, 0.43 and 0.53. Computer tomography classification was correct in 71% and in agreement with the endoscopic ultrasound classification in 56–61% (kappa 0.12 to 0.27).
Endoscopic ultrasound and computer tomography cannot accurately distinguish between benign pancreatic cystic lesions and malignant or potentially malignant ones. There is poor-to-modest interobserver agreement in classifying these lesions.
Details
- Title: Subtitle
- Endoscopic ultrasound and computer tomography are inaccurate methods of classifying cystic pancreatic lesions
- Creators
- H Gerke - Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, NC, USAT.A Jaffe - Department of Radiology, Duke University Medical Center, Durham, NC, USAR.M Mitchell - Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, NC, USAM.F Byrne - Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, NC, USAH.L Stiffler - Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, NC, USAM.S Branch - Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, NC, USAJ Baillie - Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, NC, USAP.S Jowell - Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, NC, USA
- Resource Type
- Journal article
- Publication Details
- Digestive and liver disease, Vol.38(1), pp.39-44
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/j.dld.2005.09.023
- PMID
- 16314152
- ISSN
- 1590-8658
- eISSN
- 1878-3562
- Language
- English
- Date published
- 2006
- Academic Unit
- Gastroenterology and Hepatology; Internal Medicine
- Record Identifier
- 9984094717602771
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