Journal article
Endosomal transport via ubiquitination
Trends in cell biology, Vol.21(11), pp.647-655
11/01/2011
DOI: 10.1016/j.tcb.2011.08.007
PMCID: PMC3225009
PMID: 21955996
Abstract
Cell survival, growth, differentiation and homeostasis rely on exquisite control of the abundance of particular cell-surface membrane proteins. Cell-surface proteins must respond appropriately to environmental and intracellular cues, often undergoing regulated internalization and lysosomal degradation. These proteins also can sustain damage and must be recognized and removed. A unifying mechanism has emerged for the trafficking of damaged and downregulated proteins to the lysosome by their attachment to ubiquitin (Ub), which serves as a sorting signal for clathrin-mediated internalization and sorting into late endosomes. Major questions remain as to how this system is governed, how it is adapted for different proteins, and whether Ub serves as more than a one-way ticket to the lysosome for degradation. Here, we highlight recent insights and the challenges that remain.
Details
- Title: Subtitle
- Endosomal transport via ubiquitination
- Creators
- Robert C. Piper - University of IowaPaul J. Lehner - Addenbrooke's Hospital
- Resource Type
- Journal article
- Publication Details
- Trends in cell biology, Vol.21(11), pp.647-655
- DOI
- 10.1016/j.tcb.2011.08.007
- PMID
- 21955996
- PMCID
- PMC3225009
- NLM abbreviation
- Trends Cell Biol
- ISSN
- 0962-8924
- eISSN
- 1879-3088
- Publisher
- Elsevier
- Number of pages
- 9
- Grant note
- R01GM058202 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) 084957; 091181 / Wellcome Trust; European Commission G9800943; G0600823 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); European Commission R01 GM058202-12; R01 GM058202 / NIGMS NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) G9800943 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC)
- Language
- English
- Date published
- 11/01/2011
- Academic Unit
- Molecular Physiology and Biophysics; Medicine Administration; Internal Medicine
- Record Identifier
- 9984297497002771
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