Endothelial and cardiomyocyte PI3Kβ divergently regulate cardiac remodelling in response to ischaemic injury

Xueyi Chen; Pavel Zhabyeyev; Abul K Azad; Wang Wang; Rachel A Minerath; Jessica DesAulniers; Chad E Grueter; Allan G Murray; Zamaneh Kassiri; Bart Vanhaesebroeck; Gavin Y Oudit

doi:10.1093/cvr/cvy298

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Endothelial and cardiomyocyte PI3Kβ divergently regulate cardiac remodelling in response to ischaemic injury

Journal article

Open access

Peer reviewed

Endothelial and cardiomyocyte PI3Kβ divergently regulate cardiac remodelling in response to ischaemic injury

Xueyi Chen, Pavel Zhabyeyev, Abul K Azad, Wang Wang, Rachel A Minerath, Jessica DesAulniers, Chad E Grueter, Allan G Murray, Zamaneh Kassiri, Bart Vanhaesebroeck, …

Cardiovascular research, Vol.115(8), pp.1343-1356

07/01/2019

DOI: 10.1093/cvr/cvy298

PMCID: PMC6587920

PMID: 30496354

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Abstract

Graphical Abstract

Myocardial infarction

PI3Kβ

Remodelling

Angiogenesis

Cardiomyocyte death

Original

Details

Title: Subtitle: Endothelial and cardiomyocyte PI3Kβ divergently regulate cardiac remodelling in response to ischaemic injury
Creators: Xueyi Chen - Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
Pavel Zhabyeyev - Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
Abul K Azad - Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
Wang Wang - Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada
Rachel A Minerath - Division of Cardiovascular Medicine, Department of Internal Medicine, Francois M. Abboud Cardiovascular Research Center, Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, IA, USA
Jessica DesAulniers - Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
Chad E Grueter - Division of Cardiovascular Medicine, Department of Internal Medicine, Francois M. Abboud Cardiovascular Research Center, Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, IA, USA
Allan G Murray - Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
Zamaneh Kassiri - Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada
Bart Vanhaesebroeck - University College London Cancer Institute, University College London, London, UK
Gavin Y Oudit - Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
Resource Type: Journal article
Publication Details: Cardiovascular research, Vol.115(8), pp.1343-1356
DOI: 10.1093/cvr/cvy298
PMID: 30496354
PMCID: PMC6587920
NLM abbreviation: Cardiovasc Res
ISSN: 0008-6363
eISSN: 1755-3245
Publisher: Oxford University Press
Grant note: ; ; ; 13SDG14660064 / ; ; ; ; ; R01 HL125436 / ; ; ;
Language: English
Date published: 07/01/2019
Academic Unit: Cardiovascular Medicine; Craniofacial Anomalies Research Center; Neuroscience and Pharmacology; Internal Medicine
Record Identifier: 9984094578502771

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