Endothelial dysfunction and blood pressure variability in selected inbred mouse strains

Michael J Ryan; Sean P Didion; Deborah R Davis; Frank M Faraci; Curt D Sigmund

doi:10.1161/hq0102.101098

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Endothelial dysfunction and blood pressure variability in selected inbred mouse strains

Journal article

Open access

Peer reviewed

Endothelial dysfunction and blood pressure variability in selected inbred mouse strains

Michael J Ryan, Sean P Didion, Deborah R Davis, Frank M Faraci and Curt D Sigmund

Arteriosclerosis, thrombosis, and vascular biology, Vol.22(1), pp.42-48

01/2002

DOI: 10.1161/hq0102.101098

PMID: 11788459

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Abstract

The genetic regulation of blood pressure (BP) and endothelial function is likely to be polygenic. Because there is considerable variability in basal BP among inbred mouse strains, the purpose of this study was to determine whether a similar variability in vascular function exists among 7 "normotensive" strains. We tested the hypothesis that compared with mice with higher BPs, mice with lower BPs would have greater aortic endothelial responses to acetylcholine (ACh). Mean BP ranged from 117 to 145 mm Hg among the 7 strains. The responses of aortic rings to ACh, sodium nitroprusside, and papaverine were assessed after submaximal precontraction with prostaglandin F(2alpha). The aortas from all strains relaxed in a concentration-dependent manner to sodium nitroprusside and papaverine, but responses to ACh were markedly impaired in the aortas, but not carotid arteries, from 129P3/J and 129X1/SvJ mice. Aortas from the other strains relaxed normally to ACh. Furthermore, the endothelium-dependent dilators ADP and A23187 caused similar relaxation in 129P3/J, 129X1/SvJ, and C57BL/6J mice. Although the data do not support the initial hypothesis, the impaired aortic response to ACh in the 129 strains is a novel finding and illustrates the potential impact that genetic background can have on vascular responsiveness.

Mice, Inbred Strains - genetics

Mice, Inbred Strains - physiology

Vasodilator Agents - pharmacology

Species Specificity

Acetylcholine - pharmacology

Blood Pressure - genetics

Aorta - drug effects

Endothelium, Vascular - drug effects

Male

Vasoconstriction - drug effects

Endothelium, Vascular - physiology

Dose-Response Relationship, Drug

Vasoconstriction - physiology

Animals

Heart Rate - physiology

Models, Animal

Blood Pressure - drug effects

Blood Pressure - physiology

Mice

Vasodilation - physiology

Aorta - physiology

Blood Pressure Determination

Details

Title: Subtitle: Endothelial dysfunction and blood pressure variability in selected inbred mouse strains
Creators: Michael J Ryan - Department of Internal Medicine, Cardiovascular Center, University of Iowa, Iowa City 52242, USA
Sean P Didion
Deborah R Davis
Frank M Faraci
Curt D Sigmund
Resource Type: Journal article
Publication Details: Arteriosclerosis, thrombosis, and vascular biology, Vol.22(1), pp.42-48
DOI: 10.1161/hq0102.101098
PMID: 11788459
NLM abbreviation: Arterioscler Thromb Vasc Biol
ISSN: 1079-5642
eISSN: 1524-4636
Publisher: United States
Grant note: HL-48058 / NHLBI NIH HHS HL-56006 / NHLBI NIH HHS HL-10425 / NHLBI NIH HHS HL-10237 / NHLBI NIH HHS HL-38901 / NHLBI NIH HHS NS-24621 / NINDS NIH HHS HL-61446 / NHLBI NIH HHS HL-62984 / NHLBI NIH HHS
Language: English
Date published: 01/2002
Academic Unit: Molecular Physiology and Biophysics; Pathology; Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
Record Identifier: 9984040543302771

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