Journal article
Endothelial dysfunction assessed by digital tonometry and discrepancy between fraction flow reserve and instantaneous wave free ratio
Acta Cardiologica, Vol.75(4), pp.323-328
07/03/2020
DOI: 10.1080/00015385.2019.1586089
PMID: 30945607
Abstract
Background: We tested whether the level of endothelial dysfunction assessed by digital tonometry, and expressed as reactive hyperemia index (RHI), is related to occurrences of a discrepancy between fractional flow reserve (FFR) and the instantaneous wave free ratio (iFR) (ClinicalTrials.gov identifier: NCT03033810).
Methods: We examined patients with coronary stenosis in the range of 40-70%, assessed by both FFR and iFR (system Philips-Volcano) for stable angina. We included consecutive patients with FFR and iFR in one native coronary artery, and who had had no previous intervention.
Results: We included 138 patients. Out of those, 24 patients (17.4%) had a negative FFR (with an FFR value >0.8) and positive iFR (with a iFR value ≤0.89) - designated the FFRn/iFRp discrepancy group, and 22 patients (15.9%) had a positive FFR (≤0.8) and negative iFR (>0.89) - designated the FFRp/iFRn discrepancy. RHI was higher in the discrepancy groups compared the group without discrepancy (1.73 ± 0.79 vs. 1.48 ± 0.50, p = 0.025). However, this finding was not confirmed in multivariant logistic regression analyses. Patients with any type of discrepancy differed from the agreement group by having a higher occurrence of diabetes mellitus [9 patients (21.4%) vs. 36 patients (39.6%), p = 0.029], active smoking (23 patients or 54.8% vs. 26 patients or 28.6%, p = 0.003) and lower use of calcium channel blockers (9 patients, 21.4%, vs. 43 patients, 46.7%, p = 0.004).
Conclusion: The presence of endothelial dysfunction can be associated with a discrepancy in FFR/iFR. However, RHI correlated with risk factors of atherosclerosis, not with FFR or iFR.
Details
- Title: Subtitle
- Endothelial dysfunction assessed by digital tonometry and discrepancy between fraction flow reserve and instantaneous wave free ratio
- Creators
- Stepan Jerabek - Charles UniversityDavid Zemanek - Charles UniversityJan Pudil - Charles UniversityKristyna Bayerova - Charles UniversityAles Kral - Charles UniversityKarel Kopriva - Cardiology Department, Homolka Hospital, Prague, Czech Republic.Yoshiaki Kawase - Gifu Heart Center, Gifu, Japan.Hiroyuki Omori - Gifu Heart Center, Gifu, Japan.Toru Tanigaki - Gifu Heart Center, Gifu, Japan.Zhi Chen - University of IowaAlexandra Vodzinska - Cardiology Department, Trinec Podlesi Hospital, Trinec, Czech Republic.Marian Branny - Cardiology Department, Trinec Podlesi Hospital, Trinec, Czech Republic.Hitoshi Matsuo - Gifu Heart Center, Gifu, Japan.Martin Mates - Cardiology Department, Homolka Hospital, Prague, Czech Republic.Milan Sonka - University of IowaTomas Kovarnik - Charles University
- Resource Type
- Journal article
- Publication Details
- Acta Cardiologica, Vol.75(4), pp.323-328
- DOI
- 10.1080/00015385.2019.1586089
- PMID
- 30945607
- NLM abbreviation
- Acta Cardiol
- ISSN
- 0001-5385
- eISSN
- 1784-973X
- Publisher
- Taylor & Francis
- Grant note
- AZV 16-28525A; 191415; 180501 / Czech Health Research Council
- Language
- English
- Date published
- 07/03/2020
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Electrical and Computer Engineering; Radiation Oncology; The Iowa Institute for Biomedical Imaging; Fraternal Order of Eagles Diabetes Research Center; Injury Prevention Research Center; Ophthalmology and Visual Sciences
- Record Identifier
- 9984186699202771
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