Endothelial effects of leptin: implications in health and diseases

Kamal Rahmouni; William G Haynes

doi:10.1007/s11892-005-0020-5

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Endothelial effects of leptin: implications in health and diseases

Journal article

Peer reviewed

Endothelial effects of leptin: implications in health and diseases

Kamal Rahmouni and William G Haynes

Current diabetes reports, Vol.5(4), pp.260-266

08/2005

DOI: 10.1007/s11892-005-0020-5

PMID: 16033675

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Abstract

Leptin is an adipocyte-derived hormone that plays a major role in the regulation of energy homeostasis through its action in the central nervous system. Leptin also acts on several peripheral tissues, including the vascular endothelium. The leptin receptor has been identified in endothelial cells. Leptin action on the endothelium modulates several physiologic processes, with potential implications in pathophysiologic diseases associated with obesity. Leptin stimulation of angiogenesis has attracted attention because of its potential involvement in retinopathy and atherosclerosis. Leptin activation of endothelial oxidative stress also has implications in atherosclerosis and inflammation. However, data on the impact of the endothelial effect of leptin on arterial pressure are contrasting. Although some investigators have shown that leptin action on the endothelial nitric oxide system tends to decrease arterial pressure, others have shown no contribution from the endothelial effect of leptin to the control of arterial pressure. Further characterization of the endothelial effects of leptin will, it is hoped, help in the understanding of the different pathophysiologic diseases associated with obesity.

Receptors, Leptin

Humans

Leptin - metabolism

Oxidative Stress - physiology

Receptors, Cell Surface - metabolism

Endothelium, Vascular - physiology

Obesity - metabolism

Obesity - pathology

Leptin - physiology

Animals

Endothelium, Vascular - metabolism

Endothelium, Vascular - pathology

Signal Transduction - physiology

Vasodilation - physiology

Energy Metabolism - physiology

Details

Title: Subtitle: Endothelial effects of leptin: implications in health and diseases
Creators: Kamal Rahmouni - Department of Internal Medicine and General Clinical Research Center, University of Iowa College of Medicine, Iowa City, IA 52242, USA
William G Haynes
Resource Type: Journal article
Publication Details: Current diabetes reports, Vol.5(4), pp.260-266
Publisher: United States
DOI: 10.1007/s11892-005-0020-5
PMID: 16033675
ISSN: 1534-4827
eISSN: 1539-0829
Grant note: RR00059 / NCRR NIH HHS HL44546 / NHLBI NIH HHS HL14388 / NHLBI NIH HHS
Language: English
Date published: 08/2005
Academic Unit: Iowa Neuroscience Institute; Neuroscience and Pharmacology; Internal Medicine
Record Identifier: 9984040571802771

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