Journal article
Endothelial function and white matter hyperintensities in older adults with cardiovascular disease
Stroke (1970), Vol.38(2), pp.308-312
02/2007
DOI: 10.1161/01.STR.0000254517.04275.3f
PMCID: PMC2748266
PMID: 17204686
Abstract
The presence of white matter hyperintensities on brain MRI is common among elderly individuals. Previous research suggests that cardiovascular risk factors are associated with increased white matter hyperintensities. Examining the role of direct physiological measures of vascular function will help to clarify the vascular mechanisms related to white matter hyperintensities. The aim of the present study was to examine the association between endothelial-dependent and endothelial-independent vasodilatation and white matter hyperintensity volume.
Twenty-five older adults with a range of cardiovascular diseases underwent brain MRI and completed assessments of blood vessel integrity using endothelial-dependent and independent flow-mediated dilation of the brachial artery. A semi-automated pixel-based method was used to quantify total brain volume and white matter hyperintensity volume, with white matter hyperintensity volume corrected for total brain volume. The association between measures of flow-mediated dilation and log-transformed white matter hyperintensities was examined.
Correlation analysis revealed that endothelial-dependent vasodilatation was significantly and inversely associated with white matter hyperintensity volume. In contrast, endothelial-independent vasodilatation was not associated with white matter hyperintensities. Neither endothelial-dependent nor endothelial-independent vasodilatation was associated with total brain volume.
These data provide preliminary evidence that the integrity of the vascular endothelium is associated with white matter hyperintensities in older adults with cardiovascular disease. Impaired vascular function may be one mechanism that contributes to the development of white matter hyperintensities in the brain. Additional longitudinal research combining measures of vessel function, neuroimaging and cognition will be helpful in clarifying this potential mechanism.
Details
- Title: Subtitle
- Endothelial function and white matter hyperintensities in older adults with cardiovascular disease
- Creators
- Karin F Hoth - Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI 02903, USA. Karin_Hoth@Brown.eduDavid F TateAthena PoppasDaniel E FormanJohn GunstadDavid J MoserRobert H PaulAngela L JeffersonAndreana P HaleyRonald A Cohen
- Resource Type
- Journal article
- Publication Details
- Stroke (1970), Vol.38(2), pp.308-312
- DOI
- 10.1161/01.STR.0000254517.04275.3f
- PMID
- 17204686
- PMCID
- PMC2748266
- NLM abbreviation
- Stroke
- ISSN
- 0039-2499
- eISSN
- 1524-4628
- Publisher
- United States
- Grant note
- MH065857 / NIMH NIH HHS P30 AG013846-06 / NIA NIH HHS AG017975 / NIA NIH HHS MH073416 / NIMH NIH HHS K23 MH073416 / NIMH NIH HHS P30 AG013846 / NIA NIH HHS K23 MH065857 / NIMH NIH HHS AG026850 / NIA NIH HHS F32 AG022773-02 / NIA NIH HHS R01 AG017975 / NIA NIH HHS AG022773 / NIA NIH HHS F32 HL074568 / NHLBI NIH HHS F32 AG022773 / NIA NIH HHS AG020649 / NIA NIH HHS K12 HD043444 / NICHD NIH HHS HD043444 / NICHD NIH HHS HL074568 / NHLBI NIH HHS F32 AG022773-01 / NIA NIH HHS F32 AG026850 / NIA NIH HHS K23 AG020649 / NIA NIH HHS
- Language
- English
- Date published
- 02/2007
- Academic Unit
- Psychiatry; Iowa Neuroscience Institute; Medicine Administration
- Record Identifier
- 9984004091402771
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