Endothelial interleukin-21 receptor up-regulation in peripheral artery disease

Tao Wang; Alexis Cunningham; Kevin Houston; Aditya M Sharma; Lingdan Chen; Ayotunde O Dokun; R John Lye; Rosanne Spolski; Warren J Leonard; Brian H Annex

doi:10.1177/1358863X15621798

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Endothelial interleukin-21 receptor up-regulation in peripheral artery disease

Journal article

Open access

Peer reviewed

Endothelial interleukin-21 receptor up-regulation in peripheral artery disease

Tao Wang, Alexis Cunningham, Kevin Houston, Aditya M Sharma, Lingdan Chen, Ayotunde O Dokun, R John Lye, Rosanne Spolski, Warren J Leonard and Brian H Annex

Vascular medicine (London, England), Vol.21(2), pp.99-104

12/24/2015

DOI: 10.1177/1358863X15621798

PMCID: PMC5347532

PMID: 26705256

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Abstract

In most patients with symptomatic peripheral artery disease (PAD), severe stenosis in or occlusion of the major blood vessels that supply the legs make the amount of distal blood flow dependent on the capacity to induce angiogenesis and collateral vessel formation. Currently, there are no medications that improve perfusion to the ischemic limb, and thus directly treat the primary problem of PAD. A recent report from our group in a pre-clinical mouse PAD model showed that interleukin-21 receptor (IL-21R) is up-regulated in the endothelial cells from ischemic hindlimb muscle. We further showed that loss of IL-21R resulted in impaired perfusion recovery in this model. In our study, we sought to determine whether IL-21R is present in the endothelium from ischemic muscle of patients with PAD. Using human gastrocnemius muscle biopsies, we found increased levels of IL-21R in the skeletal muscle endothelial cells of patients with PAD compared to control individuals. Interestingly, PAD patients had approximately 1.7-fold higher levels of circulating IL-21. These data provide direct evidence that the IL-21R pathway is indeed up-regulated in patients with PAD. This pathway may serve as a therapeutic target for modulation.

Ischemia

endothelial cells

IL-2R

interleukin-21 receptor

PAD

peripheral artery disease

Details

Title: Subtitle: Endothelial interleukin-21 receptor up-regulation in peripheral artery disease
Creators: Tao Wang - University of Virginia
Alexis Cunningham - University of Virginia
Kevin Houston - University of Virginia
Aditya M Sharma - University of Virginia
Lingdan Chen - University of Virginia
Ayotunde O Dokun - University of Virginia
R John Lye - University of Virginia
Rosanne Spolski - National Heart Lung and Blood Institute
Warren J Leonard - National Heart Lung and Blood Institute
Brian H Annex - University of Virginia
Resource Type: Journal article
Publication Details: Vascular medicine (London, England), Vol.21(2), pp.99-104
DOI: 10.1177/1358863X15621798
PMID: 26705256
PMCID: PMC5347532
NLM abbreviation: Vasc Med
ISSN: 1358-863X
eISSN: 1477-0377
Language: English
Date published: 12/24/2015
Academic Unit: Molecular Physiology and Biophysics; Fraternal Order of Eagles Diabetes Research Center; Endocrinology and Metabolism; Internal Medicine
Record Identifier: 9984297605102771

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