Endothelial progenitor cells in chronic obstructive pulmonary disease and emphysema

Margaret F Doyle; Russell P Tracy; Megha A Parikh; Eric A Hoffman; Daichi Shimbo; John H M Austin; Benjamin M Smith; Katja Hueper; Jens Vogel-Claussen; Joao Lima; Antoinette Gomes; Karol Watson; Steven Kawut; R Graham Barr

doi:10.1371/journal.pone.0173446

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Endothelial progenitor cells in chronic obstructive pulmonary disease and emphysema

Journal article

Open access

Peer reviewed

Endothelial progenitor cells in chronic obstructive pulmonary disease and emphysema

Margaret F Doyle, Russell P Tracy, Megha A Parikh, Eric A Hoffman, Daichi Shimbo, John H M Austin, Benjamin M Smith, Katja Hueper, Jens Vogel-Claussen, Joao Lima, …

PloS one, Vol.12(3), pp.e0173446-e0173446

2017

DOI: 10.1371/journal.pone.0173446

PMCID: PMC5349667

PMID: 28291826

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Abstract

Endothelial injury is implicated in the pathogenesis of COPD and emphysema; however the role of endothelial progenitor cells (EPCs), a marker of endothelial cell repair, and circulating endothelial cells (CECs), a marker of endothelial cell injury, in COPD and its subphenotypes is unresolved. We hypothesized that endothelial progenitor cell populations would be decreased in COPD and emphysema and that circulating endothelial cells would be increased. Associations with other subphenotypes were examined. The Multi-Ethnic Study of Atherosclerosis COPD Study recruited smokers with COPD and controls age 50-79 years without clinical cardiovascular disease. Endothelial progenitor cell populations (CD34+KDR+ and CD34+KDR+CD133+ cells) and circulating endothelial cells (CD45dimCD31+CD146+CD133-) were measured by flow cytometry. COPD was defined by standard spirometric criteria. Emphysema was assessed qualitatively and quantitatively on CT. Full pulmonary function testing and expiratory CTs were measured in a subset. Among 257 participants, both endothelial progenitor cell populations, and particularly CD34+KDR+ endothelial progenitor cells, were reduced in COPD. The CD34+KDR+CD133+ endothelial progenitor cells were associated inversely with emphysema extent. Both endothelial progenitor cell populations were associated inversely with extent of panlobular emphysema and positively with diffusing capacity. Circulating endothelial cells were not significantly altered in COPD but were inversely associated with pulmonary microvascular blood flow on MRI. There was no consistent association of endothelial progenitor cells or circulating endothelial cells with measures of gas trapping. These data provide evidence that endothelial repair is impaired in COPD and suggest that this pathological process is specific to emphysema.

Aged

Emphysema - immunology

Emphysema - pathology

Endothelial Progenitor Cells - immunology

Endothelial Progenitor Cells - pathology

Female

Flow Cytometry

Humans

Immunophenotyping

Magnetic Resonance Imaging

Male

Middle Aged

Plethysmography

Pulmonary Disease, Chronic Obstructive - immunology

Pulmonary Disease, Chronic Obstructive - pathology

Details

Title: Subtitle: Endothelial progenitor cells in chronic obstructive pulmonary disease and emphysema
Creators: Margaret F Doyle - University of Vermont
Russell P Tracy - University of Vermont
Megha A Parikh - Columbia University
Eric A Hoffman - University of Iowa
Daichi Shimbo - Columbia University
John H M Austin - Columbia University
Benjamin M Smith - Columbia University
Katja Hueper - Medizinische Hochschule Hannover
Jens Vogel-Claussen - Medizinische Hochschule Hannover
Joao Lima - Department of Cardiology, Johns Hopkins University, Baltimore, Maryland, United States of America
Antoinette Gomes - University of California, Los Angeles
Karol Watson - University of California, Los Angeles
Steven Kawut - University of Pennsylvania
R Graham Barr - Columbia University
Resource Type: Journal article
Publication Details: PloS one, Vol.12(3), pp.e0173446-e0173446
DOI: 10.1371/journal.pone.0173446
PMID: 28291826
PMCID: PMC5349667
NLM abbreviation: PLoS One
ISSN: 1932-6203
eISSN: 1932-6203
Grant note: P30 ES005605 / NIEHS NIH HHS R01 HL093081 / NHLBI NIH HHS K24 HL103844 / NHLBI NIH HHS R01 HL112986 / NHLBI NIH HHS P30 DK054759 / NIDDK NIH HHS R01 HL077612 / NHLBI NIH HHS
Language: English
Date published: 2017
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
Record Identifier: 9984318707302771

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