Journal article
Endothelium-Derived Relaxing Factor Inhibits Constrictor Responses of Large Cerebral Arteries to Serotonin
Journal of cerebral blood flow and metabolism, Vol.12(3), pp.500-506
06/29/2016
DOI: 10.1038/jcbfm.1992.68
PMID: 1569143
Abstract
Endothelium-derived relaxing factor [EDRF, nitric oxide (NO) or a NO-containing compound] influences basal tone of cerebral blood vessels and mediates vasodilation in response to several stimuli. It is not known whether EDRF also modulates responses to cerebral vasoconstrictor stimuli in vivo. Our goal was to determine whether formation of EDRF inhibits constrictor responses of large cerebral arteries to serotonin. We measured cerebral blood flow (microspheres) and pial microvascular pressure (servo null) in anesthetized rabbits and calculated resistance of large cerebral arteries. Responses to an inhibitor of NO formation, NG-nitro-l-arginine (l-NNA, 3 mg/kg i.v.), were examined. l-NNA produced an increase in resistance of large arteries and total cerebral vascular resistance of approximately 15% (p < 0.05 for both variables) and a small decrease in cerebral blood flow (35 ± 9 vs. 32 ± 7 ml min−1 100 g−1, mean ± SD, p < 0.05). Under control conditions, infusion of serotonin (10 μg kg−1 min−1, into the left atrium) produced an increase in resistance of large arteries. Following treatment with l-NNA, the change in resistance of large arteries in response to serotonin was increased more than twofold (0.20 ± 0.17 vs. 0.43 ± 0.21 mm Hg ml−1 min 100 g, p < 0.05). In contrast, l-NNA did not alter the increase in resistance of large arteries during hypocapnia. l-arginine inhibited the effects of l-NNA on baseline cerebral vascular resistance and on responses of large arteries to serotonin. Thus, formation of EDRF (NO) from l-arginine (a) has a modest influence on cerebral blood flow under basal conditions and (b) inhibits constriction of large cerebral arteries to serotonin, but not hypocapnia.
Details
- Title: Subtitle
- Endothelium-Derived Relaxing Factor Inhibits Constrictor Responses of Large Cerebral Arteries to Serotonin
- Creators
- Frank M Faraci - Departments of Internal Medicine and Pharmacology, Cardiovascular Center and Veterans Administration Medical Center, University of Iowa College of Medicine, Iowa City, Iowa, U.S.ADonald D Heistad - Departments of Internal Medicine and Pharmacology, Cardiovascular Center and Veterans Administration Medical Center, University of Iowa College of Medicine, Iowa City, Iowa, U.S.A
- Resource Type
- Journal article
- Publication Details
- Journal of cerebral blood flow and metabolism, Vol.12(3), pp.500-506
- DOI
- 10.1038/jcbfm.1992.68
- PMID
- 1569143
- NLM abbreviation
- J Cereb Blood Flow Metab
- ISSN
- 0271-678X
- eISSN
- 1559-7016
- Language
- English
- Date published
- 06/29/2016
- Academic Unit
- Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040318402771
Metrics
14 Record Views