Endothelium-derived relaxing factor modulates noradrenergic constriction of cerebral arterioles in rabbits

G C Bauknight Jr; F M Faraci; D D Heistad

doi:10.1161/01.STR.23.10.1522

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Endothelium-derived relaxing factor modulates noradrenergic constriction of cerebral arterioles in rabbits

Journal article

Open access

Peer reviewed

Endothelium-derived relaxing factor modulates noradrenergic constriction of cerebral arterioles in rabbits

G C Bauknight Jr, F M Faraci and D D Heistad

Stroke (1970), Vol.23(10), pp.1522-1526

10/1992

DOI: 10.1161/01.STR.23.10.1522

PMID: 1412591

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Abstract

Cerebral arterioles are relatively unresponsive to norepinephrine. We tested the hypothesis that release of endothelium-derived relaxing factor is stimulated by norepinephrine and attenuates adrenergic constriction of pial arterioles. In seven anesthetized New Zealand White rabbits, diameter of pial arterioles was measured through a cranial window. Responses to topical application of norepinephrine and arginine vasopressin were examined before and during application of NG-nitro-L-arginine, which inhibits synthesis of endothelium-derived relaxing factor. Norepinephrine (10(-6) M) had no effect (0 +/- 3%, mean +/- SE) on arteriolar diameter under basal conditions. Norepinephrine decreased arteriolar diameter by 15 +/- 4% during application of nitro-L-arginine (10(-4) M) (p less than 0.05 versus basal response). L-arginine inhibited the effect of nitro-L-arginine on responses of pial arterioles to norepinephrine. In contrast to norepinephrine, constrictor responses of pial arterioles to vasopressin were not potentiated by nitro-L-arginine. Norepinephrine, but not arginine vasopressin, releases endothelium-derived relaxing factor, which inhibits constrictor responses of cerebral arterioles in rabbits. This mechanism contributes to the finding that cerebral vessels in rabbits are relatively unresponsive to noradrenergic stimuli.

Norepinephrine - pharmacology

Rabbits

Acetylcholine - pharmacology

Cerebrovascular Circulation - drug effects

Nitric Oxide - antagonists & inhibitors

Nitric Oxide - pharmacology

Male

Arginine Vasopressin - pharmacology

Arterioles - drug effects

Vasoconstriction - drug effects

Arginine - analogs & derivatives

Animals

Arginine - pharmacology

Female

Nitroarginine

Details

Title: Subtitle: Endothelium-derived relaxing factor modulates noradrenergic constriction of cerebral arterioles in rabbits
Creators: G C Bauknight Jr - Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242-1009
F M Faraci
D D Heistad
Resource Type: Journal article
Publication Details: Stroke (1970), Vol.23(10), pp.1522-1526
Publisher: United States
DOI: 10.1161/01.STR.23.10.1522
PMID: 1412591
ISSN: 0039-2499
eISSN: 1524-4628
Grant note: HL-16066 / NHLBI NIH HHS HL-38901 / NHLBI NIH HHS NS-24621 / NINDS NIH HHS
Language: English
Date published: 10/1992
Academic Unit: Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
Record Identifier: 9984040570102771

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