Endothelium-specific gene and stem cell-based therapy for erectile dysfunction

Travis D Strong; Milena A Gebska; Arthur L Burnett; Hunter C Champion; Trinity J Bivalacqua

doi:10.1111/j.1745-7262.2008.00362.x

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Endothelium-specific gene and stem cell-based therapy for erectile dysfunction

Journal article

Open access

Peer reviewed

Endothelium-specific gene and stem cell-based therapy for erectile dysfunction

Travis D Strong, Milena A Gebska, Arthur L Burnett, Hunter C Champion and Trinity J Bivalacqua

Asian journal of andrology, Vol.10(1), pp.14-22

01/2008

DOI: 10.1111/j.1745-7262.2008.00362.x

PMID: 18087639

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https://doi.org/10.1111/j.1745-7262.2008.00362.xView

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Abstract

Erectile dysfunction (ED) commonly results from endothelial dysfunction of the systemic vasculature. Although phosphodiesterase type 5 (PDE-5) inhibitors are effective at treating most cases of ED, they must be taken routinely and are ineffectual for a meaningful number of men. In recent years gene and stem cell-based therapies targeted at the penile endothelium have been gaining momentum in preclinical studies. These early studies reveal that gene and stem cell-based therapies may be both enduring and efficacious, and may eventually lead to a cure for ED. The following review will highlight our current understanding of endothelial-specific gene and stem cell-based therapies performed to date in a number of experimental animal models.

Genetic Therapy

Superoxide Dismutase - genetics

Endothelial Cells

Humans

Male

Vascular Endothelial Growth Factor A - genetics

Nitric Oxide Synthase Type III - genetics

Stem Cell Transplantation

Animals

Erectile Dysfunction - therapy

Multipotent Stem Cells - transplantation

Cell Differentiation

Endothelium, Vascular

Details

Title: Subtitle: Endothelium-specific gene and stem cell-based therapy for erectile dysfunction
Creators: Travis D Strong - Department of Urology, Johns Hopkins Hospital, Baltimore, MD 21287, USA
Milena A Gebska
Arthur L Burnett
Hunter C Champion
Trinity J Bivalacqua
Resource Type: Journal article
Publication Details: Asian journal of andrology, Vol.10(1), pp.14-22
DOI: 10.1111/j.1745-7262.2008.00362.x
PMID: 18087639
NLM abbreviation: Asian J Androl
ISSN: 1008-682X
eISSN: 1745-7262
Language: English
Date published: 01/2008
Academic Unit: Cardiovascular Medicine; Internal Medicine
Record Identifier: 9984094315602771

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