Journal article
Endotoxin Enhancement as a Possible Etiology of Early-Onset Group B Beta-Hemolytic Streptococcal Sepsis in the Newborn
Obstetrics and gynecology (New York. 1953), Vol.61(5), pp.588-592
05/1983
PMID: 6340011
Abstract
Group B streptococcal cells, either viable or heat-killed, contain a substance that induced fever in rabbits with maximal responses occurring four hours after intravenous injection. In contrast, supernatant fluids failed to induce significant fever. Group B streptococcal cells also enhanced host susceptibility to lethal shock by endotoxin as much as 40,000-fold. A graph of log streptococcal cell dose used for pretreatment versus log LD50 endotoxin gave a straight line with a slope of approximately -1. Rabbits that received both streptococcal cells and endotoxin showed initial fever followed by hypothermia, labored breathing, watery diarrhea, evidence of vascular collapse, and finally death. Animals that received streptococcal cells or endotoxin alone showed only fevers and mild diarrhea. A possible theory for the cause of death in the neonate infected with group B streptococci is presented.
Details
- Title: Subtitle
- Endotoxin Enhancement as a Possible Etiology of Early-Onset Group B Beta-Hemolytic Streptococcal Sepsis in the Newborn
- Creators
- Patrick Schlievert - From the Department of Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota; and the Departments of Obstetrics and Gynecology and of Microbiology, University of Iowa College of Medicine, Iowa City, IowaMichael VarnerRudolph Galask
- Resource Type
- Journal article
- Publication Details
- Obstetrics and gynecology (New York. 1953), Vol.61(5), pp.588-592
- Publisher
- The American College of Obstetricians and Gynecologists
- PMID
- 6340011
- ISSN
- 0029-7844
- eISSN
- 1873-233X
- Language
- English
- Date published
- 05/1983
- Academic Unit
- Microbiology and Immunology; Internal Medicine
- Record Identifier
- 9984001156302771
Metrics
25 Record Views