Endotoxin and β-1,3-d-Glucan in Concentrated Ambient Particles Induce Rapid Increase in Blood Pressure in Controlled Human Exposures

Jia Zhong; Bruce Urch; Mary Speck; Brent A Coull; Petros Koutrakis; Peter S Thorne; James Scott; Ling Liu; Robert D Brook; Behrooz Behbod; Heike Gibson; Frances Silverman; Murray A Mittleman; Andrea A Baccarelli; Diane R Gold

doi:10.1161/HYPERTENSIONAHA.115.05342

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Endotoxin and β-1,3-d-Glucan in Concentrated Ambient Particles Induce Rapid Increase in Blood Pressure in Controlled Human Exposures

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Endotoxin and β-1,3-d-Glucan in Concentrated Ambient Particles Induce Rapid Increase in Blood Pressure in Controlled Human Exposures

Jia Zhong, Bruce Urch, Mary Speck, Brent A Coull, Petros Koutrakis, Peter S Thorne, James Scott, Ling Liu, Robert D Brook, Behrooz Behbod, …

Hypertension (Dallas, Tex. 1979), Vol.66(3), pp.509-516

09/2015

DOI: 10.1161/HYPERTENSIONAHA.115.05342

PMCID: PMC4537367

PMID: 26123683

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Abstract

Short-term exposure to particulate matter (PM) is associated with increased blood pressure (BP) in epidemiological studies. Understanding the impact of specific PM components on BP is essential in developing effective risk-reduction strategies. We investigated the association between endotoxin and β-1,3-d-Glucan-two major biological PM components-and BP. We also examined whether vascular endothelial growth factor, a vasodilatory inflammatory marker, modified these associations. We conducted a single-blind, randomized, crossover trial of controlled human exposure to concentrated ambient particles with 50 healthy adults. Particle-associated-endotoxin and β-1,3-d-Glucan were sampled using polycarbonate-membrane-filters. Supine resting systolic BP and diastolic BP were measured pre-, 0.5-hour post-, and 20-hour postexposure. Urine vascular endothelial growth factor concentration was determined using enzyme-linked immunosorbant assay and creatinine-corrected. Exposures to endotoxin and β-1,3-d-Glucan for 130 minutes were associated with increases in BPs: at 0.5-hour postexposure, every doubling in endotoxin concentration was associated with 1.73 mm Hg higher systolic BP (95% confidence interval, 0.28, 3.18; P=0.02) and 2.07 mm Hg higher diastolic BP (95% confidence interval, 0.74, 3.39; P=0.003); every doubling in β-1,3-d-Glucan concentration was associated with 0.80 mm Hg higher systolic BP (95% confidence interval, -0.07, 1.67; P=0.07) and 0.88 mm Hg higher diastolic BP (95% confidence interval, 0.09, 1.66; P=0.03). Vascular endothelial growth factor rose after concentrated ambient particle endotoxin exposure and attenuated the association between endotoxin and 0.5-hour postexposure diastolic BP (Pinteraction=0.02). In healthy adults, short-term endotoxin and β-1,3-d-Glucan exposures were associated with increased BP. Our findings suggest that the biological PM components contribute to PM-related cardiovascular outcomes, and postexposure vascular endothelial growth factor elevation might be an adaptive response that attenuates these effects.

Single-Blind Method

Humans

Middle Aged

Male

Cross-Over Studies

Young Adult

Air Pollutants

Inhalation Exposure

Adolescent

Endotoxins - administration & dosage

beta-Glucans - administration & dosage

Adult

Female

Blood Pressure - drug effects

Blood Pressure Determination

Particulate Matter - administration & dosage

Details

Title: Subtitle: Endotoxin and β-1,3-d-Glucan in Concentrated Ambient Particles Induce Rapid Increase in Blood Pressure in Controlled Human Exposures
Creators: Jia Zhong - Harvard University
Bruce Urch - From the Department of Environmental Health (J.Z., P.K., B.B., H.G., A.A.B., D.R.G.), Department of Biostatistics (B.A.C.), and Department of Epidemiology (M.A.M.), Harvard T.H. Chan School of Public Health, Boston, MA; Division of Occupational & Environmental Health, Dalla Lana School of Public Health (J.S., F.S.), Department of Medicine (B.U., J.S., F.S.), and Divisions of Occupational and Respiratory Medicine, Department of Medicine (F.S.), University of Toronto, Toronto, Ontario, Canada; Department of Occupational and Environmental Health, University of Iowa (P.S.T.); Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario, Canada (L.L.); Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI (R.D.B.); Li Ka Shing Knowledge Institute (F.S.), St Michael's Hospital (M.S., J.S., F.S.), Toronto, Ontario, Canada; Southern Ontario Center for Atmospheric Aerosol Research, Toronto, Ontario, Canada (F.S.); and Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (D.R.G.)
Mary Speck - From the Department of Environmental Health (J.Z., P.K., B.B., H.G., A.A.B., D.R.G.), Department of Biostatistics (B.A.C.), and Department of Epidemiology (M.A.M.), Harvard T.H. Chan School of Public Health, Boston, MA; Division of Occupational & Environmental Health, Dalla Lana School of Public Health (J.S., F.S.), Department of Medicine (B.U., J.S., F.S.), and Divisions of Occupational and Respiratory Medicine, Department of Medicine (F.S.), University of Toronto, Toronto, Ontario, Canada; Department of Occupational and Environmental Health, University of Iowa (P.S.T.); Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario, Canada (L.L.); Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI (R.D.B.); Li Ka Shing Knowledge Institute (F.S.), St Michael's Hospital (M.S., J.S., F.S.), Toronto, Ontario, Canada; Southern Ontario Center for Atmospheric Aerosol Research, Toronto, Ontario, Canada (F.S.); and Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (D.R.G.)
Brent A Coull - From the Department of Environmental Health (J.Z., P.K., B.B., H.G., A.A.B., D.R.G.), Department of Biostatistics (B.A.C.), and Department of Epidemiology (M.A.M.), Harvard T.H. Chan School of Public Health, Boston, MA; Division of Occupational & Environmental Health, Dalla Lana School of Public Health (J.S., F.S.), Department of Medicine (B.U., J.S., F.S.), and Divisions of Occupational and Respiratory Medicine, Department of Medicine (F.S.), University of Toronto, Toronto, Ontario, Canada; Department of Occupational and Environmental Health, University of Iowa (P.S.T.); Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario, Canada (L.L.); Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI (R.D.B.); Li Ka Shing Knowledge Institute (F.S.), St Michael's Hospital (M.S., J.S., F.S.), Toronto, Ontario, Canada; Southern Ontario Center for Atmospheric Aerosol Research, Toronto, Ontario, Canada (F.S.); and Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (D.R.G.)
Petros Koutrakis - From the Department of Environmental Health (J.Z., P.K., B.B., H.G., A.A.B., D.R.G.), Department of Biostatistics (B.A.C.), and Department of Epidemiology (M.A.M.), Harvard T.H. Chan School of Public Health, Boston, MA; Division of Occupational & Environmental Health, Dalla Lana School of Public Health (J.S., F.S.), Department of Medicine (B.U., J.S., F.S.), and Divisions of Occupational and Respiratory Medicine, Department of Medicine (F.S.), University of Toronto, Toronto, Ontario, Canada; Department of Occupational and Environmental Health, University of Iowa (P.S.T.); Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario, Canada (L.L.); Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI (R.D.B.); Li Ka Shing Knowledge Institute (F.S.), St Michael's Hospital (M.S., J.S., F.S.), Toronto, Ontario, Canada; Southern Ontario Center for Atmospheric Aerosol Research, Toronto, Ontario, Canada (F.S.); and Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (D.R.G.)
Peter S Thorne - From the Department of Environmental Health (J.Z., P.K., B.B., H.G., A.A.B., D.R.G.), Department of Biostatistics (B.A.C.), and Department of Epidemiology (M.A.M.), Harvard T.H. Chan School of Public Health, Boston, MA; Division of Occupational & Environmental Health, Dalla Lana School of Public Health (J.S., F.S.), Department of Medicine (B.U., J.S., F.S.), and Divisions of Occupational and Respiratory Medicine, Department of Medicine (F.S.), University of Toronto, Toronto, Ontario, Canada; Department of Occupational and Environmental Health, University of Iowa (P.S.T.); Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario, Canada (L.L.); Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI (R.D.B.); Li Ka Shing Knowledge Institute (F.S.), St Michael's Hospital (M.S., J.S., F.S.), Toronto, Ontario, Canada; Southern Ontario Center for Atmospheric Aerosol Research, Toronto, Ontario, Canada (F.S.); and Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (D.R.G.)
James Scott - University of Toronto
Ling Liu - Health Canada
Robert D Brook - From the Department of Environmental Health (J.Z., P.K., B.B., H.G., A.A.B., D.R.G.), Department of Biostatistics (B.A.C.), and Department of Epidemiology (M.A.M.), Harvard T.H. Chan School of Public Health, Boston, MA; Division of Occupational & Environmental Health, Dalla Lana School of Public Health (J.S., F.S.), Department of Medicine (B.U., J.S., F.S.), and Divisions of Occupational and Respiratory Medicine, Department of Medicine (F.S.), University of Toronto, Toronto, Ontario, Canada; Department of Occupational and Environmental Health, University of Iowa (P.S.T.); Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario, Canada (L.L.); Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI (R.D.B.); Li Ka Shing Knowledge Institute (F.S.), St Michael's Hospital (M.S., J.S., F.S.), Toronto, Ontario, Canada; Southern Ontario Center for Atmospheric Aerosol Research, Toronto, Ontario, Canada (F.S.); and Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (D.R.G.)
Behrooz Behbod - From the Department of Environmental Health (J.Z., P.K., B.B., H.G., A.A.B., D.R.G.), Department of Biostatistics (B.A.C.), and Department of Epidemiology (M.A.M.), Harvard T.H. Chan School of Public Health, Boston, MA; Division of Occupational & Environmental Health, Dalla Lana School of Public Health (J.S., F.S.), Department of Medicine (B.U., J.S., F.S.), and Divisions of Occupational and Respiratory Medicine, Department of Medicine (F.S.), University of Toronto, Toronto, Ontario, Canada; Department of Occupational and Environmental Health, University of Iowa (P.S.T.); Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario, Canada (L.L.); Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI (R.D.B.); Li Ka Shing Knowledge Institute (F.S.), St Michael's Hospital (M.S., J.S., F.S.), Toronto, Ontario, Canada; Southern Ontario Center for Atmospheric Aerosol Research, Toronto, Ontario, Canada (F.S.); and Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (D.R.G.)
Heike Gibson - From the Department of Environmental Health (J.Z., P.K., B.B., H.G., A.A.B., D.R.G.), Department of Biostatistics (B.A.C.), and Department of Epidemiology (M.A.M.), Harvard T.H. Chan School of Public Health, Boston, MA; Division of Occupational & Environmental Health, Dalla Lana School of Public Health (J.S., F.S.), Department of Medicine (B.U., J.S., F.S.), and Divisions of Occupational and Respiratory Medicine, Department of Medicine (F.S.), University of Toronto, Toronto, Ontario, Canada; Department of Occupational and Environmental Health, University of Iowa (P.S.T.); Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario, Canada (L.L.); Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI (R.D.B.); Li Ka Shing Knowledge Institute (F.S.), St Michael's Hospital (M.S., J.S., F.S.), Toronto, Ontario, Canada; Southern Ontario Center for Atmospheric Aerosol Research, Toronto, Ontario, Canada (F.S.); and Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (D.R.G.)
Frances Silverman - From the Department of Environmental Health (J.Z., P.K., B.B., H.G., A.A.B., D.R.G.), Department of Biostatistics (B.A.C.), and Department of Epidemiology (M.A.M.), Harvard T.H. Chan School of Public Health, Boston, MA; Division of Occupational & Environmental Health, Dalla Lana School of Public Health (J.S., F.S.), Department of Medicine (B.U., J.S., F.S.), and Divisions of Occupational and Respiratory Medicine, Department of Medicine (F.S.), University of Toronto, Toronto, Ontario, Canada; Department of Occupational and Environmental Health, University of Iowa (P.S.T.); Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario, Canada (L.L.); Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI (R.D.B.); Li Ka Shing Knowledge Institute (F.S.), St Michael's Hospital (M.S., J.S., F.S.), Toronto, Ontario, Canada; Southern Ontario Center for Atmospheric Aerosol Research, Toronto, Ontario, Canada (F.S.); and Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (D.R.G.)
Murray A Mittleman - From the Department of Environmental Health (J.Z., P.K., B.B., H.G., A.A.B., D.R.G.), Department of Biostatistics (B.A.C.), and Department of Epidemiology (M.A.M.), Harvard T.H. Chan School of Public Health, Boston, MA; Division of Occupational & Environmental Health, Dalla Lana School of Public Health (J.S., F.S.), Department of Medicine (B.U., J.S., F.S.), and Divisions of Occupational and Respiratory Medicine, Department of Medicine (F.S.), University of Toronto, Toronto, Ontario, Canada; Department of Occupational and Environmental Health, University of Iowa (P.S.T.); Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario, Canada (L.L.); Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI (R.D.B.); Li Ka Shing Knowledge Institute (F.S.), St Michael's Hospital (M.S., J.S., F.S.), Toronto, Ontario, Canada; Southern Ontario Center for Atmospheric Aerosol Research, Toronto, Ontario, Canada (F.S.); and Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (D.R.G.)
Andrea A Baccarelli - From the Department of Environmental Health (J.Z., P.K., B.B., H.G., A.A.B., D.R.G.), Department of Biostatistics (B.A.C.), and Department of Epidemiology (M.A.M.), Harvard T.H. Chan School of Public Health, Boston, MA; Division of Occupational & Environmental Health, Dalla Lana School of Public Health (J.S., F.S.), Department of Medicine (B.U., J.S., F.S.), and Divisions of Occupational and Respiratory Medicine, Department of Medicine (F.S.), University of Toronto, Toronto, Ontario, Canada; Department of Occupational and Environmental Health, University of Iowa (P.S.T.); Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario, Canada (L.L.); Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI (R.D.B.); Li Ka Shing Knowledge Institute (F.S.), St Michael's Hospital (M.S., J.S., F.S.), Toronto, Ontario, Canada; Southern Ontario Center for Atmospheric Aerosol Research, Toronto, Ontario, Canada (F.S.); and Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (D.R.G.)
Diane R Gold - From the Department of Environmental Health (J.Z., P.K., B.B., H.G., A.A.B., D.R.G.), Department of Biostatistics (B.A.C.), and Department of Epidemiology (M.A.M.), Harvard T.H. Chan School of Public Health, Boston, MA; Division of Occupational & Environmental Health, Dalla Lana School of Public Health (J.S., F.S.), Department of Medicine (B.U., J.S., F.S.), and Divisions of Occupational and Respiratory Medicine, Department of Medicine (F.S.), University of Toronto, Toronto, Ontario, Canada; Department of Occupational and Environmental Health, University of Iowa (P.S.T.); Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario, Canada (L.L.); Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI (R.D.B.); Li Ka Shing Knowledge Institute (F.S.), St Michael's Hospital (M.S., J.S., F.S.), Toronto, Ontario, Canada; Southern Ontario Center for Atmospheric Aerosol Research, Toronto, Ontario, Canada (F.S.); and Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (D.R.G.)
Resource Type: Journal article
Publication Details: Hypertension (Dallas, Tex. 1979), Vol.66(3), pp.509-516
Publisher: United States
DOI: 10.1161/HYPERTENSIONAHA.115.05342
PMID: 26123683
PMCID: PMC4537367
ISSN: 0194-911X
eISSN: 1524-4563
Grant note: P30 ES005605 / NIEHS NIH HHS RD-83241601 / ORD VA P30ES005605 / NIEHS NIH HHS ES000002 / NIEHS NIH HHS P01 ES009825 / NIEHS NIH HHS P30 ES000002 / NIEHS NIH HHS RD-83479801 / ORD VA
Language: English
Date published: 09/2015
Academic Unit: Civil and Environmental Engineering; Occupational and Environmental Health
Record Identifier: 9983997324602771

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