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Endotoxin inhalation alters lung development in neonatal mice
Journal article   Open access   Peer reviewed

Endotoxin inhalation alters lung development in neonatal mice

Katarina Kulhankova, Caroline L S George, Joel N Kline, Melissa Darling and Peter S Thorne
American journal of industrial medicine, Vol.55(12), pp.1146-1158
12/2012
DOI: 10.1002/ajim.22061
PMCID: PMC3549999
PMID: 22576659
url
https://www.ncbi.nlm.nih.gov/pmc/articles/3549999View
Open Access

Abstract

Childhood asthma is a significant public health problem. Epidemiologic evidence suggests an association between childhood asthma exacerbations and early life exposure to environmental endotoxin. Although the pathogenesis of endotoxin-induced adult asthma is well studied, questions remain about the impact of environmental endotoxin on pulmonary responsiveness in early life. We developed a murine model of neonatal/juvenile endotoxin exposures approximating those in young children and evaluated the lungs inflammatory and remodeling responses. Persistent lung inflammation induced by the inhalation of endotoxin in early life was demonstrated by the influx of inflammatory cells and pro-inflammatory mediators to the airways and resulted in abnormal alveolarization. Results of this study advance the understanding of the impact early life endotoxin inhalation has on the lower airways, and demonstrates the importance of an experimental design that approximates environmental exposures as they occur in young children.
 Animals, Newborn Lung - pathology Administration, Inhalation Toxicity Tests, Subchronic Mice, Inbred C3H Chemokines - analysis Animals Lung - drug effects Endotoxins - administration & dosage Bronchoalveolar Lavage Fluid - cytology Lung - growth & development Mice Bronchoalveolar Lavage Fluid - chemistry Endotoxins - toxicity Disease Models, Animal

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