Journal article
Endotoxin temporarily impairs canine jejunal absorption of water, electrolytes, and glucose
Journal of gastrointestinal surgery, Vol.1(3), pp.286-291
06/1997
DOI: 10.1016/S1091-255X(97)80122-9
PMID: 9834360
Abstract
Enteral feeding during and after episodes of sepsis may be beneficial. The aim of our study was to determine the effects of a single sublethal dose of endotoxin on canine jejunal absorption. Following a 240 kcal liquid meal, absorption studies were performed in eight dogs with 75 cm jejunal Thiry-Vella fistulas. These fistulas were perfused with an isotonic solution containing polyethylene glycol to calculate absorption. Each dog was then given a single dose ofEscherichia coli lipopolysaccharide, 200 μg/kg intravenously, and the studies were repeated for the next 3 days. Following endotoxin bolus infusion, net absorption of water, electrolytes and glucose was decreased for 2 days and returned to baseline values on postendotoxin day 3. A single sublethal dose of endotoxin temporarily impairs canine jejunal absorption. Although enteral feeding may be advantageous, jejunal absorption may be temporarily impaired following an episode of endotoxemia.
Details
- Title: Subtitle
- Endotoxin temporarily impairs canine jejunal absorption of water, electrolytes, and glucose
- Creators
- Joseph Cullen - Department of Surgery University of Iowa College of Medicine and Veterans Affairs Medical Center Iowa City IowaLynda Hemann - Department of Surgery University of Iowa College of Medicine and Veterans Affairs Medical Center Iowa City IowaKimberly Ephgrave - Department of Surgery University of Iowa College of Medicine and Veterans Affairs Medical Center Iowa City IowaMarilyn Hinkhous - Department of Surgery University of Iowa College of Medicine and Veterans Affairs Medical Center Iowa City Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of gastrointestinal surgery, Vol.1(3), pp.286-291
- Publisher
- Springer-Verlag; Berlin/Heidelberg
- DOI
- 10.1016/S1091-255X(97)80122-9
- PMID
- 9834360
- ISSN
- 1091-255X
- eISSN
- 1873-4626
- Language
- English
- Date published
- 06/1997
- Academic Unit
- Surgery; Radiation Oncology; Internal Medicine
- Record Identifier
- 9984051542402771
Metrics
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