Journal article
Engaging Nonaromatic, Heterocyclic Tosylates in Reductive Cross-Coupling with Aryl and Heteroaryl Bromides
Journal of organic chemistry, Vol.80(5), pp.2907-2911
03/06/2015
DOI: 10.1021/acs.joc.5b00135
PMID: 25711834
Abstract
A method has been developed for the introduction of nonaromatic heterocyclic structures onto aryl and heteroaryl bromides using alkyl tosylates in a reductive cross-coupling manifold. This protocol offers an improvement over previous methods by utilizing alkyl tosylate coupling partners that are bench-stable, crystalline solids that can be prepared from inexpensive, commercially available alcohols.
Details
- Title: Subtitle
- Engaging Nonaromatic, Heterocyclic Tosylates in Reductive Cross-Coupling with Aryl and Heteroaryl Bromides
- Creators
- Gary A Molander - Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United StatesKaitlin M Traister - Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United StatesBrian T O’Neill - Pfizer Worldwide Medicinal Chemistry, Eastern Point Road, Groton, Connecticut 06340, United States
- Resource Type
- Journal article
- Publication Details
- Journal of organic chemistry, Vol.80(5), pp.2907-2911
- DOI
- 10.1021/acs.joc.5b00135
- PMID
- 25711834
- NLM abbreviation
- J Org Chem
- ISSN
- 0022-3263
- eISSN
- 1520-6904
- Grant note
- DOI: 10.13039/100004319, name: Pfizer
- Language
- English
- Date published
- 03/06/2015
- Academic Unit
- Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984094526002771
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