Journal article
Engaging communities in therapeutics clinical research during pandemics: Experiences and lessons from the ACTIV COVID-19 therapeutics research initiative
Journal of clinical and translational science, Vol.8(1), p.e156
2024
DOI: 10.1017/cts.2024.561
PMID: 39540112
Abstract
This manuscript addresses a critical topic: navigating complexities of conducting clinical trials during a pandemic. Central to this discussion is engaging communities to ensure diverse participation. The manuscript elucidates deliberate strategies employed to recruit minority communities with poor social drivers of health for participation in COVID-19 trials. The paper adopts a descriptive approach, eschewing analysis of data-driven efficacy of these efforts, and instead provides a comprehensive account of strategies utilized. The Accelerate COVID-19 Treatment Interventions and Vaccines (ACTIV) public-private partnership launched early in the COVID-19 pandemic to develop clinical trials to advance SARS-CoV-2 treatments. In this paper, ACTIV investigators share challenges in conducting research during an evolving pandemic and approaches selected to engage communities when traditional strategies were infeasible. Lessons from this experience include importance of community representatives' involvement early in study design and implementation and integration of well-developed public outreach and communication strategies with trial launch. Centralization and coordination of outreach will allow for efficient use of resources and the sharing of best practices. Insights gleaned from the ACTIV program, as outlined in this paper, shed light on effective strategies for involving communities in treatment trials amidst rapidly evolving public health emergencies. This underscores critical importance of community engagement initiatives well in advance of the pandemic.
Details
- Title: Subtitle
- Engaging communities in therapeutics clinical research during pandemics: Experiences and lessons from the ACTIV COVID-19 therapeutics research initiative
- Creators
- David A. Wohl - University of North Carolina at Chapel HillStacey J. Adam - Foundation for the National Institutes of HealthKevin W. Gibbs - Wake Forest UniversityAri L. Moskowitz - Montefiore Medical CenterThomas L. Ortel - Duke UniversityUpinder Singh - Stanford UniversityNikolaus Jilg - Brigham and Women's HospitalTeresa H. Evering - Weill Cornell MedicineWilliam A. Fischer - University of North Carolina at Chapel HillBabafemi O. Taiwo - Northwestern UniversityEric S. Daar - University of California, Los AngelesChristopher J. Lindsell - Duke UniversitySusanna Naggie - Duke UniversityRussell L. Rothman - Vanderbilt UniversitySarah E. Dunsmore - National Institutes of HealthM. Patricia McAdams - Duke UniversityJulia Vail - Duke UniversityDushyantha Jayaweera - University of Miami
- Resource Type
- Journal article
- Publication Details
- Journal of clinical and translational science, Vol.8(1), p.e156
- DOI
- 10.1017/cts.2024.561
- PMID
- 39540112
- NLM abbreviation
- J Clin Transl Sci
- ISSN
- 2059-8661
- eISSN
- 2059-8661
- Publisher
- Cambridge Univ Press
- Number of pages
- 12
- Grant note
- Foundation for the National Institutes of Health (FNIH) Various US government funding agencies
- Language
- English
- Date published
- 2024
- Academic Unit
- Internal Medicine
- Record Identifier
- 9985244549502771
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