Engineering Intrinsically Zirconium‐89 Radiolabeled Self‐Destructing Mesoporous Silica Nanostructures for In Vivo Biodistribution and Tumor Targeting Studies

Shreya Goel; Feng Chen; Shijie Luan; Hector F. Valdovinos; Sixiang Shi; Stephen A. Graves; Fanrong Ai; Todd E. Barnhart; Charles P. Theuer; Weibo Cai

doi:10.1002/advs.201600122

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Engineering Intrinsically Zirconium‐89 Radiolabeled Self‐Destructing Mesoporous Silica Nanostructures for In Vivo Biodistribution and Tumor Targeting Studies

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Engineering Intrinsically Zirconium‐89 Radiolabeled Self‐Destructing Mesoporous Silica Nanostructures for In Vivo Biodistribution and Tumor Targeting Studies

Shreya Goel, Feng Chen, Shijie Luan, Hector F. Valdovinos, Sixiang Shi, Stephen A. Graves, Fanrong Ai, Todd E. Barnhart, Charles P. Theuer and Weibo Cai

Advanced science, Vol.3(11), pp.1600122-n/a

11/2016

DOI: 10.1002/advs.201600122

PMCID: PMC5102673

PMID: 27980987

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https://doi.org/10.1002/advs.201600122View

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Abstract

A systematic study of in vitro and in vivo behavior of biodegradable mesoporous silica nanoparticles (bMSNs), designed to carry multiple cargos (both small and macromolecular drugs) and subsequently self‐destruct following release of their payloads, is presented. Complete degradation of bMSNs is seen within 21 d of incubation in simulated body fluid. The as‐synthesized bMSNs are intrinsically radiolabeled with oxophilic zirconium‐89 ( 89 Zr, t 1/2 = 78.4 h) radionuclide to track their in vivo pharmacokinetics via positron emission tomography imaging. Rapid and persistent CD105 specific tumor vasculature targeting is successfully demonstrated in murine model of metastatic breast cancer by using TRC105 (an anti‐CD105 antibody)‐conjugated bMSNs. This study serves to illustrate a simple, versatile, and readily tunable approach to potentially overcome the current challenges facing nanomedicine and further the goals of personalized nanotheranostics.

biodegradable mesoporous silica nanoparticles

intrinsic radiolabeling

positron emission tomography (PET) imaging

vasculature targeting

Details

Title: Subtitle: Engineering Intrinsically Zirconium‐89 Radiolabeled Self‐Destructing Mesoporous Silica Nanostructures for In Vivo Biodistribution and Tumor Targeting Studies
Creators: Shreya Goel - University of Wisconsin–Madison
Feng Chen - University of Wisconsin–Madison
Shijie Luan - Temple University
Hector F. Valdovinos - University of Wisconsin–Madison
Sixiang Shi - University of Wisconsin–Madison
Stephen A. Graves - University of Wisconsin–Madison
Fanrong Ai - University of Wisconsin–Madison
Todd E. Barnhart - University of Wisconsin–Madison
Charles P. Theuer - Tracon Pharmaceuticals (United States)
Weibo Cai - University of Wisconsin–Madison
Resource Type: Journal article
Publication Details: Advanced science, Vol.3(11), pp.1600122-n/a
DOI: 10.1002/advs.201600122
PMID: 27980987
PMCID: PMC5102673
NLM abbreviation: Adv Sci (Weinh)
ISSN: 2198-3844
eISSN: 2198-3844
Publisher: John Wiley and Sons Inc
Language: English
Date published: 11/2016
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Radiation Oncology
Record Identifier: 9984383899502771

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