Journal article
Engineering a 3D vascular network in hydrogel for mimicking a nephron
Lab on a chip, Vol.13(8), pp.1612-1618
01/01/2013
DOI: 10.1039/c3lc41342j
PMID: 23455642
Abstract
Engineering functional vascular networks in vitro is critical for tissue engineering and a variety of applications. There is still a general lack of straightforward approaches for recapitulating specific structures and functions of vasculature. This report describes a microfluidic method that utilizes fibrillogenesis of collagen and a liquid mold to engineer three-dimensional vascular networks in hydrogel. The well-controlled vascular network demonstrates both mechanical stability for perfusing solutions and biocompatibility for cell adhesion and coverage. This technique enables the mimicry of passive diffusion in a nephron one of the main routes transferring soluble organic molecules. This approach could be used for in vitro modelling of mass transfer-involved physiology in vasculature-rich tissues and organs for regeneration and drug screening.
Details
- Title: Subtitle
- Engineering a 3D vascular network in hydrogel for mimicking a nephron
- Creators
- Xuan Mu - Chinese Academy of Medical Sciences & Peking Union Medical CollegeWenfu Zheng - National Center for Nanoscience and TechnologyLe Xiao - National Center for Nanoscience and TechnologyWei Zhang - National Center for Nanoscience and TechnologyXingyu Jiang - National Center for Nanoscience and Technology
- Resource Type
- Journal article
- Publication Details
- Lab on a chip, Vol.13(8), pp.1612-1618
- Publisher
- Royal Soc Chemistry
- DOI
- 10.1039/c3lc41342j
- PMID
- 23455642
- ISSN
- 1473-0197
- eISSN
- 1473-0189
- Number of pages
- 7
- Grant note
- KJCX2-YW-M15 / Chinese Academy of Sciences 20100480246 / China Postdoctoral Science Foundation 2012AA022703; 2012AA030608; 2011CB933201; 2009CB930001 / Ministry of Science and Technology 21025520; 51073045; GZ 614; 91213305 / National Science Foundation of China; National Natural Science Foundation of China (NSFC) 2013ZX09507005 / State Major Scientific and Technological Project of China K. C. Wong Education Foundation
- Language
- English
- Date published
- 01/01/2013
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering
- Record Identifier
- 9984276456902771
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