Journal article
Engineering nanomedicines using stimuli-responsive biomaterials
Advanced drug delivery reviews, Vol.64(11), pp.1021-1030
08/2012
DOI: 10.1016/j.addr.2012.01.003
PMCID: PMC3422739
PMID: 22266128
Abstract
The ability to engineer particles has the potential to shift the paradigm in the creation of new medicines and diagnostics. Complete control over particle characteristics, such as size, shape, mechanical property, and surface chemistry, can enable rapid translation and facilitate the US Food and Drug Administration (FDA) approval of particle technologies for the treatment of cancer, infectious diseases, diabetes, and a host of other major illnesses. The incorporation of natural and artificial external stimuli to trigger the release of drugs enables exquisite control over the release profiles of drugs in a given environment. In this article, we examine several readily scalable top–down methods for the fabrication of shape-specific particles that utilize stimuli-responsive biomaterials for controlled drug delivery. Special attention is given to Particle Replication In Nonwetting Templates (PRINT®) technology and the application of novel triggered-release synthetic and natural polymers.
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Details
- Title: Subtitle
- Engineering nanomedicines using stimuli-responsive biomaterials
- Creators
- Yapei Wang - University of North Carolina at Chapel HillJames D Byrne - University of North Carolina at Chapel HillMary E Napier - University of North Carolina at Chapel HillJoseph M DeSimone - University of North Carolina at Chapel Hill
- Resource Type
- Journal article
- Publication Details
- Advanced drug delivery reviews, Vol.64(11), pp.1021-1030
- DOI
- 10.1016/j.addr.2012.01.003
- PMID
- 22266128
- PMCID
- PMC3422739
- NLM abbreviation
- Adv Drug Deliv Rev
- ISSN
- 0169-409X
- eISSN
- 1872-8294
- Publisher
- Elsevier B.V
- Language
- English
- Date published
- 08/2012
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiation Oncology
- Record Identifier
- 9984274756302771
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