Journal article
Enhanced Leptin-Stimulated Pi3k Activation in the CNS Promotes White Adipose Tissue Transdifferentiation
Cell metabolism, Vol.6(6), pp.431-445
2007
DOI: 10.1016/j.cmet.2007.10.012
PMID: 18054313
Abstract
The contribution of different leptin-induced signaling pathways in control of energy homeostasis is only partly understood. Here we show that selective Pten ablation in leptin-sensitive neurons (Pten
ΔObRb) results in enhanced Pi3k activation in these cells and reduces adiposity by increasing energy expenditure. White adipose tissue (WAT) of Pten
ΔObRb mice shows characteristics of brown adipose tissue (BAT), reflected by increased mitochondrial content and Ucp1 expression resulting from enhanced leptin-stimulated sympathetic nerve activity (SNA) in WAT. In contrast, leptin-deficient
ob/ob-Pten
ΔObRb mice exhibit unaltered body weight and WAT morphology compared to
ob/ob mice, pointing to a pivotal role of endogenous leptin in control of WAT transdifferentiation. Leanness of Pten
ΔObRb mice is accompanied by enhanced sensitivity to insulin in skeletal muscle. These data provide direct genetic evidence that leptin-stimulated Pi3k signaling in the CNS regulates energy expenditure via activation of SNA to perigonadal WAT leading to BAT-like differentiation of WAT.
Details
- Title: Subtitle
- Enhanced Leptin-Stimulated Pi3k Activation in the CNS Promotes White Adipose Tissue Transdifferentiation
- Creators
- Leona Plum - Department of Mouse Genetics and Metabolism, Institute for Genetics, University of Cologne and Center of Molecular Medicine Cologne (CMMC), D-50674 Cologne, GermanyEva Rother - Department of Mouse Genetics and Metabolism, Institute for Genetics, University of Cologne and Center of Molecular Medicine Cologne (CMMC), D-50674 Cologne, GermanyHeike Münzberg - Division of Metabolism, Endocrinology and Diabetes, Departments of Internal Medicine and Molecular and Physiology, University of Michigan Medical School, Ann Arbor, MI 48109-0638, USAF. Thomas Wunderlich - Department of Mouse Genetics and Metabolism, Institute for Genetics, University of Cologne and Center of Molecular Medicine Cologne (CMMC), D-50674 Cologne, GermanyDonald A Morgan - Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USABrigitte Hampel - Department of Mouse Genetics and Metabolism, Institute for Genetics, University of Cologne and Center of Molecular Medicine Cologne (CMMC), D-50674 Cologne, GermanyMarya Shanabrough - Department of Obstetrics, Gynecology & Reproductive Sciences and Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06520, USARuth Janoschek - Department of Mouse Genetics and Metabolism, Institute for Genetics, University of Cologne and Center of Molecular Medicine Cologne (CMMC), D-50674 Cologne, GermanyA. Christine Könner - Department of Mouse Genetics and Metabolism, Institute for Genetics, University of Cologne and Center of Molecular Medicine Cologne (CMMC), D-50674 Cologne, GermanyJens Alber - Department of Mouse Genetics and Metabolism, Institute for Genetics, University of Cologne and Center of Molecular Medicine Cologne (CMMC), D-50674 Cologne, GermanyAkira Suzuki - Department of Molecular Biology, Akita University School of Medicine, Akita, JapanWilhelm Krone - Klinik II und Poliklinik für Innere Medizin der Universität zu Köln, D-50931 Cologne, GermanyTamas L Horvath - Department of Obstetrics, Gynecology & Reproductive Sciences and Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06520, USAKamal Rahmouni - Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USAJens C Brüning - Department of Mouse Genetics and Metabolism, Institute for Genetics, University of Cologne and Center of Molecular Medicine Cologne (CMMC), D-50674 Cologne, Germany
- Resource Type
- Journal article
- Publication Details
- Cell metabolism, Vol.6(6), pp.431-445
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.cmet.2007.10.012
- PMID
- 18054313
- ISSN
- 1550-4131
- eISSN
- 1932-7420
- Language
- English
- Date published
- 2007
- Academic Unit
- Iowa Neuroscience Institute; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040542902771
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