Journal article
Enhanced analgesic activity by cyclodextrins - a systematic review and meta-analysis
Expert opinion on drug delivery, Vol.12(10), pp.1677-1688
2015
DOI: 10.1517/17425247.2015.1046835
PMID: 26159048
Abstract
Analgesics can be ineffective in treating some types of pain, hence, improved drug delivery systems could optimize their efficacy.
The authors conducted a systematic review to evaluate the analgesic activity of compounds complexed in cyclodextrins, analyzing whether these complexes improved analgesic efficacy. The search terms 'analgesics', 'cyclodextrins' and 'drug effects' were used to retrieve articles in SCOPUS, PUBMED and EMBASE. A total of 22 papers were identified. In the clinical studies, there was greater efficacy in the complexed drug when compared with control groups, with differences ranging from 25 to 83%. Through a meta-analysis, the preclinical studies showed that the complexed drug had a significantly (p < 0.01) greater effect than the non-complexed drug.
The use of cyclodextrins can improve the efficacy of analgesic compounds, and they are an important tool in the search for greater analgesic effect. They may also be a way to reduce the therapeutic doses, and hence increasing the potential of the drug.
Details
- Title: Subtitle
- Enhanced analgesic activity by cyclodextrins - a systematic review and meta-analysis
- Creators
- Renan G Brito - b 2 University of Iowa, Carver College of Medicine, Physical Therapy and Rehabilitation Science , Iowa City, IA, USAAdriano A S Araújo - c 3 Federal University of Sergipe, Department of Pharmacy , São Cristóvão, Sergipe, BrazilJullyana S S Quintans - a 1 Federal University of Sergipe, Department of Physiology , São Cristóvão, Sergipe, Brazil +55 79 2105 6640 ; lucindojr@gmail.com ; lucindo@pq.cnpq.brKathleen A Sluka - b 2 University of Iowa, Carver College of Medicine, Physical Therapy and Rehabilitation Science , Iowa City, IA, USALucindo J Quintans-Júnior - b 2 University of Iowa, Carver College of Medicine, Physical Therapy and Rehabilitation Science , Iowa City, IA, USA
- Resource Type
- Journal article
- Publication Details
- Expert opinion on drug delivery, Vol.12(10), pp.1677-1688
- Publisher
- England
- DOI
- 10.1517/17425247.2015.1046835
- PMID
- 26159048
- ISSN
- 1742-5247
- eISSN
- 1744-7593
- Grant note
- R01 AR061371 / NIAMS NIH HHS R01 AR052316 / NIAMS NIH HHS
- Language
- English
- Date published
- 2015
- Academic Unit
- Iowa Neuroscience Institute; Nursing; Physical Therapy and Rehabilitation Science; Neuroscience and Pharmacology
- Record Identifier
- 9984040004602771
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