Enhanced bactericidal activity of Arm and Hammer Dental Care

D R Drake; K Vargas; A Cardenzana; R Srikantha

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Enhanced bactericidal activity of Arm and Hammer Dental Care

Journal article

Peer reviewed

Enhanced bactericidal activity of Arm and Hammer Dental Care

D R Drake, K Vargas, A Cardenzana and R Srikantha

American journal of dentistry, Vol.8(6), pp.308-312

12/1995

PMID: 8695008

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Abstract

To compare and contrast antibacterial activities of a baking soda-containing dentifrice, Arm and Hammer Dental Care (AHDC) with two fluoride dentifrices without baking soda (Crest and Colgate). A biphasic approach was taken, utilizing newly-developed laboratory model systems to: (1) assess the activity of brief exposure to dentifrices on single and mixed cultures; and (2) determine the effect of multiple, short-term exposure of sucrose-colonized Streptococcus mutans to simulate cumulative activity against cariogenic plaque. The short-term exposure assays revealed that S. mutans was significantly more susceptible to AHDC than either Crest of Colgate (P<0.05). Moreover, exposure of mixed suspensions of bacteria by AHDC resulted in complete killing of Actinomyces viscosus and significantly greater decreases in S. mutans (P<0.05). This enhanced bactericidal effect was not due to an alkaline pH as pH-adjusted AHDC solutions exhibited similar activity. The comprehensive in vitro plaque studies showed that exposure of colonized S. mutans to AHDC resulted in significantly greater decreases in numbers of viable cells than Crest (P<0.05). Under the conditions employed, the baking soda-containing AHDC exhibited greater antibacterial efficacy overall than the standard Crest or Colgate pastes. These studies suggest that the use of AHDC may provide additional clinical benefit as a result of the enhanced bactericidal activity.

Silicon Dioxide - pharmacology

Toothpastes

Streptococcus mutans - growth & development

Actinomyces viscosus - drug effects

Anti-Infective Agents, Local - pharmacology

Hydrogen Peroxide

Silicon Dioxide - chemistry

Sodium Bicarbonate - pharmacology

Sodium Fluoride - chemistry

Sodium Fluoride - pharmacology

Streptococcus mutans - drug effects

Colony Count, Microbial

Dental Plaque - prevention & control

Dentifrices - chemistry

Dentifrices - pharmacology

Streptococcus sanguis - growth & development

Microbial Sensitivity Tests

Analysis of Variance

Silicic Acid

Streptococcus sanguis - drug effects

Cariostatic Agents - pharmacology

Sodium Bicarbonate - chemistry

Actinomyces viscosus - growth & development

Hydrogen-Ion Concentration

Details

Title: Subtitle: Enhanced bactericidal activity of Arm and Hammer Dental Care
Creators: D R Drake - Dows Institute for Dental Research, College of Dentistry, University of Iowa, Iowa City 52242, USA
K Vargas
A Cardenzana
R Srikantha
Resource Type: Journal article
Publication Details: American journal of dentistry, Vol.8(6), pp.308-312
Publisher: United States
PMID: 8695008
ISSN: 0894-8275
Language: English
Date published: 12/1995
Academic Unit: Endodontics; Dental Research
Record Identifier: 9984065984302771

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14 Times Cited - Web of Science