Enhanced conditioned “liking” of novel visual cues paired with alcohol or non-alcohol beverage container images among individuals at higher risk for alcohol use disorder

Roberto U. Cofresí; Thomas M. Piasecki; Bruce D. Bartholow; Todd R. Schachtman

doi:10.1007/s00213-022-06231-4

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Enhanced conditioned “liking” of novel visual cues paired with alcohol or non-alcohol beverage container images among individuals at higher risk for alcohol use disorder

Journal article

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Enhanced conditioned “liking” of novel visual cues paired with alcohol or non-alcohol beverage container images among individuals at higher risk for alcohol use disorder

Roberto U. Cofresí, Thomas M. Piasecki, Bruce D. Bartholow and Todd R. Schachtman

Psychopharmacology, Vol.239(11), pp.3567-3578

11/01/2022

DOI: 10.1007/s00213-022-06231-4

PMCID: PMC9464611

PMID: 36094618

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Abstract

Rationale/Objective This study used an evaluative conditioning (EC) procedure to assess the affective properties of a CS for ingested drug reward in humans. Specifically, the study tested whether the evaluative response (“liking”/”disliking”) to an arbitrary visual stimulus (“CS 2 ,” e.g., a purple hexagon) could be changed through pairings with an alcohol or non-alcohol beverage cue (“CS 1 ,” e.g., a full wine glass, a juice box), which is ostensibly a conditioned visual predictive stimulus for alcohol or non-alcohol liquid reward, respectively. Methods Participants ( N = 369, 18–23 years, 66% female, 79% white, 21% reporting no alcohol use ever or in the past year) received 24 CS 1 pairings with each CS 2 . CS 2 and CS 1 evaluations were assessed pre- and post-conditioning. Results Alcohol and non-alcohol CS 2 “liking” correlated with alcohol use. “Liking” of the alcohol but not non-alcohol CS 1 also correlated with alcohol use. Alcohol CS 1 “liking” also correlated with alcohol and non-alcohol CS 2 ‘liking,” whereas non-alcohol CS 1 ‘liking” correlated with non-alcohol but not alcohol CS 2 “liking.” Conclusions Taken together, findings support the idea that drug-related visual stimuli acquire appetitive (hedonic and/or incentive) properties as a function of individual differences in drug use, which entail individual differences in exposure to the conditioning effects of addictive substances like alcohol. Findings also suggest a link between drug use and the propensity to attribute affective/motivational significance to reward-predictive cues in general.

Biomedical and Life Sciences

Biomedicine

Neurosciences

Original Investigation

Pharmacology/Toxicology

Psychiatry

Details

Title: Subtitle: Enhanced conditioned “liking” of novel visual cues paired with alcohol or non-alcohol beverage container images among individuals at higher risk for alcohol use disorder
Creators: Roberto U. Cofresí - University of Missouri
Thomas M. Piasecki - University of Wisconsin–Madison
Bruce D. Bartholow - University of Missouri
Todd R. Schachtman - University of Missouri
Resource Type: Journal article
Publication Details: Psychopharmacology, Vol.239(11), pp.3567-3578
DOI: 10.1007/s00213-022-06231-4
PMID: 36094618
PMCID: PMC9464611
NLM abbreviation: Psychopharmacology (Berl)
ISSN: 0033-3158
eISSN: 1432-2072
Publisher: Springer Berlin Heidelberg
Grant note: AA025451; AA025451; AA013526; AA025451-[04/05]S1; AA029169 / National Institute on Alcohol Abuse and Alcoholism (http://dx.doi.org/10.13039/100000027)
Language: English
Date published: 11/01/2022
Academic Unit: Psychological and Brain Sciences; Iowa Neuroscience Institute
Record Identifier: 9984446524002771

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