Enhanced coronary vasoconstrictive response to serotonin subsides after removal of dietary cholesterol in atherosclerotic monkeys

K G Lamping; D J Piegors; K H Benzuly; M L Armstrong; D D Heistad

doi:10.1161/01.ATV.14.6.951

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Enhanced coronary vasoconstrictive response to serotonin subsides after removal of dietary cholesterol in atherosclerotic monkeys

Journal article

Open access

Enhanced coronary vasoconstrictive response to serotonin subsides after removal of dietary cholesterol in atherosclerotic monkeys

K G Lamping, D J Piegors, K H Benzuly, M L Armstrong and D D Heistad

Arteriosclerosis and thrombosis, Vol.14(6), pp.951-957

06/1994

DOI: 10.1161/01.ATV.14.6.951

PMID: 8199187

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Abstract

Constriction in response to serotonin is enhanced in the coronary arteries of atherosclerotic monkeys. The main objective of the present study was to determine whether abnormal responses to serotonin in atherosclerosis are reversed following removal of dietary cholesterol. In addition, we examined the effect of an atherogenic diet and reduction in dietary cholesterol on vascular responses to activation of ATP-sensitive K+ channels with aprikalim. Diameters of small coronary arteries were measured on the epicardial surface of the left ventricle in vivo by using stroboscopic illumination synchronized to the heart cycle to visually freeze the motion of the heart. Diameters were measured with a microscope-video system during topical application of two vasoconstrictor agonists, serotonin and the thromboxane mimetic U46619, and the vasodilator agonists aprikalim and nitroprusside. Responses were compared in normal (n = 9), atherosclerotic (n = 14; high-cholesterol diet), and regression (n = 8; high-cholesterol diet followed by normal diet) monkeys. Constriction of coronary arteries in response to serotonin was enhanced in monkeys on an atherogenic diet and was normal in regression monkeys. Vasoconstriction in response to U46619 and vasodilation in response to nitroprusside and aprikalim were not altered by atherosclerosis. Thus, abnormal vascular responses to serotonin in small coronary arteries of atherosclerotic monkeys without morphological evidence of disease can be reversed to normal by reducing dietary cholesterol.

Vasoconstrictor Agents - pharmacology

Prostaglandin Endoperoxides, Synthetic - pharmacology

Thromboxane A2 - analogs & derivatives

Coronary Vessels - pathology

Picolines - pharmacology

Vasodilator Agents - pharmacology

15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid

Potassium Channels - physiology

Macaca fascicularis

Male

Nitroprusside - pharmacology

Potassium Channels - drug effects

Serotonin - pharmacology

Vasoconstriction - drug effects

Adenosine Triphosphate - pharmacology

Animals

Coronary Artery Disease - physiopathology

Cholesterol, Dietary - pharmacology

Coronary Artery Disease - pathology

Vasodilation - drug effects

Pyrans - pharmacology

Thromboxane A2 - pharmacology

Details

Title: Subtitle: Enhanced coronary vasoconstrictive response to serotonin subsides after removal of dietary cholesterol in atherosclerotic monkeys
Creators: K G Lamping - Department of Internal Medicine, University of Iowa, Iowa City, IA 52242
D J Piegors
K H Benzuly
M L Armstrong
D D Heistad
Resource Type: Journal article
Publication Details: Arteriosclerosis and thrombosis, Vol.14(6), pp.951-957
Publisher: United States
DOI: 10.1161/01.ATV.14.6.951
PMID: 8199187
ISSN: 1049-8834
eISSN: 2330-9199
Grant note: HL16066 / NHLBI NIH HHS HL14388 / NHLBI NIH HHS HL39050 / NHLBI NIH HHS
Language: English
Date published: 06/1994
Academic Unit: Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
Record Identifier: 9984040479002771

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