Enhanced phagocytosis of Candida species mediated by opsonization with a recombinant human antibody single-chain variable fragment

Melanie Wellington; Joseph M Bliss; Constantine G Haidaris

doi:10.1128/IAI.71.12.7228-7231.2003

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Enhanced phagocytosis of Candida species mediated by opsonization with a recombinant human antibody single-chain variable fragment

Journal article

Open access

Peer reviewed

Enhanced phagocytosis of Candida species mediated by opsonization with a recombinant human antibody single-chain variable fragment

Melanie Wellington, Joseph M Bliss and Constantine G Haidaris

Infection and immunity, Vol.71(12), pp.7228-7231

12/2003

DOI: 10.1128/IAI.71.12.7228-7231.2003

PMCID: PMC308946

PMID: 14638823

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Abstract

Specific antibody opsonization significantly enhances the level of phagocytosis of Candida in the absence of complement. Furthermore, we have described a system using a recombinant human antibody single-chain variable fragment that allows a comparative study of phagocytosis of multiple Candida species opsonized via a common antigen.

Humans

Neutrophils - immunology

Opsonin Proteins - metabolism

Monocytes - immunology

Antibodies, Fungal - immunology

Candida - classification

Immunoglobulin Fragments - immunology

Recombinant Proteins - immunology

Antibodies, Fungal - genetics

Immunoglobulin Fragments - genetics

Immunoglobulin Variable Region

Candida - immunology

Phagocytosis

Details

Title: Subtitle: Enhanced phagocytosis of Candida species mediated by opsonization with a recombinant human antibody single-chain variable fragment
Creators: Melanie Wellington - Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
Joseph M Bliss
Constantine G Haidaris
Resource Type: Journal article
Publication Details: Infection and immunity, Vol.71(12), pp.7228-7231
DOI: 10.1128/IAI.71.12.7228-7231.2003
PMID: 14638823
PMCID: PMC308946
NLM abbreviation: Infect Immun
ISSN: 0019-9567
eISSN: 1098-5522
Grant note: T32 AI007464 / NIAID NIH HHS T32 AI07464 / NIAID NIH HHS
Language: English
Date published: 12/2003
Academic Unit: Stead Family Department of Pediatrics; Infectious Disease (Pediatrics)
Record Identifier: 9984093460602771

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