Journal article
Enhancement of Uranium Ionization Efficiencies Using Zn-MOF-74 Derived Nanoporous Ion Emitters for Thermal Ionization Mass Spectrometry
Analytical chemistry (Washington), Vol.97(19), pp.10200-10207
05/20/2025
DOI: 10.1021/acs.analchem.4c06921
PMID: 40324145
Abstract
The recent introduction of nanoporous ion emitters (nano-PIEs) formed from metal–organic frameworks (MOFs) has demonstrated their potential to enhance sensitivity for thermal ionization mass spectrometry (TIMS). Nano-PIEs take advantage of the parent MOF’s chemical and structural tunability to form scaffolds for ion emitters. A study by Barpaga et al., 2023 on MOF-74 as the parent material found that with high volatility metals in their framework, uranium sample utilization efficiency (SUE) increases by up to 9-fold (e.g., Zn-MOF-74) compared to that of the analyte on a bare filament (∼0.05%). In this study, we investigate the performance of Zn-MOF-74 to maximize uranium efficiencies at the trace level (= 10–12 g) by altering the parent MOF morphology and chemistry (i.e., MOF crystal sizes and thermal degradation) and optimizing its integration with TIMS (i.e., MOF mass on a filament and ramp conditions). We observed improvement in SUE up to 20 times (≤1.0%) that of a bare filament load when nano-PIEs derived from nanocrystals of Zn-MOF-74 were heated under a specific current ramp condition. This demonstrates that rates of nano-PIE structural collapse during TIMS analysis and the subsequently formed nanomaterials (and their features) can be tuned to control the analyte ionization.
Details
- Title: Subtitle
- Enhancement of Uranium Ionization Efficiencies Using Zn-MOF-74 Derived Nanoporous Ion Emitters for Thermal Ionization Mass Spectrometry
- Creators
- Ji-Hye Seo - Pacific Northwest National LaboratoryAbhishek Kumar - Pacific Northwest National LaboratoryDushyant Barpaga - Pacific Northwest National LaboratoryKyle A. Makovsky - Pacific Northwest National LaboratoryMichael A. Sinnwell - University of IowaEirik J. Krogstad - Pacific Northwest National LaboratoryKelly McHugh - Pacific Northwest National Laboratory
- Resource Type
- Journal article
- Publication Details
- Analytical chemistry (Washington), Vol.97(19), pp.10200-10207
- DOI
- 10.1021/acs.analchem.4c06921
- PMID
- 40324145
- NLM abbreviation
- Anal Chem
- ISSN
- 0003-2700
- eISSN
- 1520-6882
- Publisher
- American Chemical Society
- Number of pages
- 8
- Language
- English
- Date published
- 05/20/2025
- Academic Unit
- Chemistry
- Record Identifier
- 9984936507302771
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