Journal article
Enhancement of host susceptibility to lethal endotoxin shock by staphylococcal pyrogenic exotoxin type C
Infection and immunity, Vol.36(1), pp.123-128
04/1982
DOI: 10.1128/IAI.36.1.123-128.1982
PMCID: PMC351193
PMID: 7042568
Abstract
Staphylococcal pyrogenic exotoxin (PE) ty pe C enhanced the susceptibility of rabbits to lethal shock by endotoxin by as much as 50,000-fold. A graph of log PE type C dose used for pretreatment versus log 50% lethal dose of endotoxin gave a straight line with a slope of approximately -1. Rabbits that received PE type C alone showed fevers only, but those given both PE ty pe C and endotoxin showed initial fever followed by hypothermia, labored breathing, diarrhea, evidence of vascular collapse, and finally death. When a PE type C dose of 3 micrograms/kg was used, pretreatment of the animals with PE for 2 h before giving the endotoxin was required to obtain maximal susceptibility. However, when 15 micrograms of PE type C per kg was utilized, the endotoxin could be given before, concurrently, or after PE type C. The capacity of PE type C to prepare rabbits for enhanced susceptibility to endotoxin was lost after 24 to 48 h. Animals could be protected from enhanced susceptibility to endotoxin by prior immunization with either PE type C or endotoxin. However, 30% of the rabbits which were immunized with PE type C failed to develop immunity, and after three injections of PE type C, these animals developed gram-negative bacteremia and succumbed. In addition, rabbits with diarrhea initially, possibly caused by Pasteurella infection, died less than 24 h after a single injection of PE type C.
Details
- Title: Subtitle
- Enhancement of host susceptibility to lethal endotoxin shock by staphylococcal pyrogenic exotoxin type C
- Creators
- P M Schlievert
- Resource Type
- Journal article
- Publication Details
- Infection and immunity, Vol.36(1), pp.123-128
- Publisher
- United States
- DOI
- 10.1128/IAI.36.1.123-128.1982
- PMID
- 7042568
- PMCID
- PMC351193
- ISSN
- 0019-9567
- eISSN
- 1098-5522
- Grant note
- AI 18359 / NIAID NIH HHS
- Language
- English
- Date published
- 04/1982
- Academic Unit
- Microbiology and Immunology; Internal Medicine
- Record Identifier
- 9984002383802771
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