Journal article
Enhancing Craniofacial Bone Reconstruction with Clinically Applicable 3D Bioprinted Constructs
Advanced healthcare materials, Vol.13(4), 2302508
02/2024
DOI: 10.1002/adhm.202302508
PMCID: PMC11250468
PMID: 37906084
Abstract
Abstract Medical imaging and 3D bioprinting can be used to create patient‐specific bone scaffolds with complex shapes and controlled inner architectures. This study investigated the effectiveness of a biomimetic approach to scaffold design by employing geometric control. The biomimetic scaffold with a dense external layer showed improved bone regeneration compared to the control scaffold. New bone filled the defected region in the biomimetic scaffolds, while the control scaffolds only presented new bone at the boundary. Histological examination also showed effective bone regeneration in the biomimetic scaffolds, while fibrotic tissue ingrowth was observed in the control scaffolds. These findings suggest that the biomimetic bone scaffold, designed to minimize competition for fibrotic tissue formation in the bony defect, can enhance bone regeneration. This study underscores the notion that patient‐specific anatomy can be accurately translated into a 3D bioprinting strategy through medical imaging, leading to the fabrication of constructs with significant clinical relevance. This article is protected by copyright. All rights reserved
Details
- Title: Subtitle
- Enhancing Craniofacial Bone Reconstruction with Clinically Applicable 3D Bioprinted Constructs
- Creators
- Hyeongjin Lee - Wake Forest UniversityCarlos Kengla - Wake Forest UniversityHan Su Kim - Ewha Womans UniversityIckhee Kim - Wake Forest UniversityJae‐Gu Cho - Wake Forest UniversityEric Renteria - Wake Forest UniversityKyungsup Shin - University of IowaAnthony Atala - Forest InstituteJames J. Yoo - Wake Forest UniversitySang Jin Lee - Wake Forest University
- Resource Type
- Journal article
- Publication Details
- Advanced healthcare materials, Vol.13(4), 2302508
- DOI
- 10.1002/adhm.202302508
- PMID
- 37906084
- PMCID
- PMC11250468
- NLM abbreviation
- Adv Healthc Mater
- ISSN
- 2192-2640
- eISSN
- 2192-2659
- Grant note
- DOI: 10.13039/100007485, name: Armed Forces Institute of Regenerative Medicine, award: W81XWH‐14‐2‐0004; DOI: 10.13039/100000002, name: National Institutes of Health, award: 1P41EB023833, 1R01DE031285
- Language
- English
- Electronic publication date
- 10/31/2023
- Date published
- 02/2024
- Academic Unit
- Orthodontics; Craniofacial Anomalies Research Center
- Record Identifier
- 9984503055402771
Metrics
21 Record Views