Journal article
Enhancing the antibacterial effect of dental adhesives with DMAHDM by incorporating MPC monomer: A systematic review and meta-analysis of in vitro studies
International journal of adhesion and adhesives, Vol.135, 103849
12/2024
DOI: 10.1016/j.ijadhadh.2024.103849
Abstract
This systematic review aims to analyze if the combination of MPC and DMAHDM can enhance the antibacterial potential of DMAHDM without impairing the adhesive system's bond strength.
A search was conducted on PubMed, Embase, Scopus, and Web of Science databases. Study selection was performed in two stages by two calibrated reviewers independently. The meta-analyses were conducted with the RevMan 5.4 software and evaluated metabolic activity (MA), lactic acid production (LA), protein repellent function (PRF), and dentin shear bond strength (DSBS) comparing DMAHDM vs. DMAHDM + MPC. The measure of effect was the mean or standardized mean difference. Quality assessment was evaluated with an adapted tool from a previous systematic review.
The initial search resulted in 158 articles. Four articles were included in the final sample. The meta-analyses evidenced a statistically significant difference favoring the use of MPC to enhance DMAHDM's antibacterial potential for inhibiting MA (SMD, 3.74; 95 % CI, 2.66, 4.83), LA (MD, −1.24; 95 % CI, −1.42, −1.06), while providing protein-repellent function (MD, −5.38; 95 % CI, −6.35, −4.41). The addition of MPC had a negative effect on DSBS in comparison to DMAHDM alone (MD, −4.23; 95 % CI, −5.63, −2.83).
The addition of MPC to DMAHDM-containing adhesives enhances the antibacterial efficacy and provides protein-repellent function, but impairs the bond strength. Future studies should test the addition of 5 % MPC.
•The combination of MPC with DMAHDM enhances the antibacterial potential of dental adhesives.•The combination of MPC with DMAHDM provides lower bacterial metabolic activity.•The combination of MPC with DMAHDM provides lower lactic acid production.•The inclusion of MPC provides protein-repellent function.•The inclusion of 7.5 % MPC impairs dental adhesive bond strength.
Details
- Title: Subtitle
- Enhancing the antibacterial effect of dental adhesives with DMAHDM by incorporating MPC monomer: A systematic review and meta-analysis of in vitro studies
- Creators
- Francisca Jennifer Duarte de Oliveira - Universidade Federal do Rio Grande do NorteBárbara Faria de Sá Barbosa - Universidade Federal do Rio Grande do NorteMariana Silva de Bessa - Universidade Federal do Rio Grande do NorteKaiza de Sousa Santos - Universidade Federal do Rio Grande do NorteMoan Jéfter Fernandes Costa - Universidade de PernambucoDiana Ferreira Gadelha de Araújo - Universidade Federal do Rio Grande do NorteVictor Pinheiro Feitosa - Department of Operative Dentistry, College of Dentistry, University of Iowa, 801 Newton Rd, Iowa City, USABoniek Castillo Dutra Borges - Universidade Federal do Rio Grande do Norte
- Resource Type
- Journal article
- Publication Details
- International journal of adhesion and adhesives, Vol.135, 103849
- DOI
- 10.1016/j.ijadhadh.2024.103849
- ISSN
- 0143-7496
- eISSN
- 1879-0127
- Publisher
- Elsevier Ltd
- Grant note
- Coordination for the Improvement of Higher Education Personnel (CAPES): 88887.706007/2022-00, 88887.907567/2023-00, 88887.685472/2022-00 National Council for Scientific and Technological Development (CNPq): 147431/2023-9
This work was supported by the Coordination for the Improvement of Higher Education Personnel (CAPES) (grants 88887.706007/2022-00, 88887.907567/2023-00, 88887.685472/2022-00) , and the National Council for Scientific and Technological Development (CNPq) (grant 147431/2023-9) . The funding source did not participate specifically in the design, collection, analysis, interpretation of data, writing, or deciding the submission for publication.
- Language
- English
- Date published
- 12/2024
- Academic Unit
- Operative Dentistry
- Record Identifier
- 9984722561402771
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