Enlarged blind spots in chorioretinal inflammatory disorders

Chittaranjan V Reddy; Jeremiah Brown Jr; James C Folk; Alan E Kimura; Sunil Gupta; Jonathan  Walker

doi:10.1016/S0161-6420(96)30645-3

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Enlarged blind spots in chorioretinal inflammatory disorders

Journal article

Peer reviewed

Enlarged blind spots in chorioretinal inflammatory disorders

Chittaranjan V Reddy, Jeremiah Brown Jr, James C Folk, Alan E Kimura, Sunil Gupta and Jonathan Walker

Ophthalmology (Rochester, Minn.), Vol.103(4), pp.606-617

04/1996

DOI: 10.1016/S0161-6420(96)30645-3

PMID: 8618760

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Abstract

This study was undertaken to better characterize patients with multifocal choroiditis and panuveitis (MCP), punctate inner choroidopathy (PIC), multiple evanescent white dot syndrome (MEWDS), and diffuse subretinal fibrosis syndrome. The specific aim was to determine whether these disorders were different entities or part of a spectrum of diseases with similar features. Seventy-nine patients were included in this study. Most of the patients have been followed up prospectively since July 1980 with some found retrospectively. Forty-one patients had MCP, 16 had PIC, 6 had diffuse subretinal fibrosis syndrome, and 16 had MEWDS. Patients with MCP had visual loss and visual field defects caused directly by visible lesions or recurrent inflammation around old lesions. In particular, clustering of lesions around the optic nerve and nasal periphery was seen in patients with MCP and appeared to be related to visual field loss. Patients with PIC also had enlarged blind spot and other field defects explained by fundus lesions. Patients with PIC and MCP did not have recurrent lesions on extended follow-up. Patients with diffuse subretinal fibrosis syndrome represented a subset of patients characterized with lesions in the posterior pole, sever scarring, and visual loss. Patients with MEWDS had the least inflammation with symmetrically distributed lesions. Minimal permanent chorioretinal scarring was seen in patients with MEWDS. Visual field defects improved in most patients with MEWDS and PIC, whereas most patients with MCP and diffuse subretinal fibrosis syndrome did not improve. Although enlarged blind spots are a feature of all four disorders, other clinical, angiographic, and electroretinographic evidence suggest that these are different entities.

Prospective Studies

Choroid Diseases - complications

Humans

Middle Aged

Choroiditis - complications

Male

Chorioretinitis - diagnosis

Choroiditis - diagnosis

Visual Fields

Panuveitis - diagnosis

Adult

Female

Child

Fluorescein Angiography

Electroretinography

Panuveitis - complications

Chorioretinitis - complications

Adolescent

Fibrosis

Choroid Diseases - diagnosis

Fundus Oculi

Retina - pathology

Optic Disk - pathology

Hypertrophy

Vision Disorders - etiology

Details

Title: Subtitle: Enlarged blind spots in chorioretinal inflammatory disorders
Creators: Chittaranjan V Reddy - Department of Ophthalmology, The University of Iowa Hospitals and Clinics, Iowa City, USA
Jeremiah Brown Jr
James C Folk
Alan E Kimura
Sunil Gupta
Jonathan Walker
Resource Type: Journal article
Publication Details: Ophthalmology (Rochester, Minn.), Vol.103(4), pp.606-617
Publisher: United States
DOI: 10.1016/S0161-6420(96)30645-3
PMID: 8618760
ISSN: 0161-6420
eISSN: 1549-4713
Language: English
Date published: 04/1996
Academic Unit: Ophthalmology and Visual Sciences
Record Identifier: 9983980087502771

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