Journal article
Enlarged hippocampal fissure in psychosis of epilepsy
Epilepsy & behavior, Vol.111, p.107290
10/2020
DOI: 10.1016/j.yebeh.2020.107290
PMID: 32759068
Abstract
Psychosis of epilepsy (POE) can be a devastating condition, and its neurobiological basis remains unclear. In a previous study, we identified reduced posterior hippocampal volumes in patients with POE. The hippocampus can be further subdivided into anatomically and functionally distinct subfields that, along with the hippocampal fissure, have been shown to be selectively affected in other psychotic disorders and are not captured by gross measures of hippocampal volume. Therefore, in this study, we compared the volume of selected hippocampal subfields and the hippocampal fissure in 31 patients with POE with 31 patients with epilepsy without psychosis. Cortical reconstruction, volumetric segmentation, and calculation of hippocampal subfields and the hippocampal fissure were performed using FreeSurfer. The group with POE had larger hippocampal fissures bilaterally compared with controls with epilepsy, which was significant on the right. There were no significant differences in the volumes of the hippocampal subfields between the two groups. Our findings suggest abnormal development of the hippocampus in POE. They support and expand the neurodevelopmental model of psychosis, which holds that early life stressors lead to abnormal neurodevelopmental processes, which underpin the onset of psychosis in later life. In line with this model, the findings of the present study suggest that enlarged hippocampal fissures may be a biomarker of abnormal neurodevelopment and risk for psychosis in patients with epilepsy.
•This is the first study of hippocampal subfields in psychosis of epilepsy (POE)•The POE group had larger hippocampal fissures bilaterally compared to epilepsy controls, which was significant on the right•This finding suggests abnormal development of the hippocampus in POE•Enlarged hippocampal fissures may be a biomarker of abnormal neurodevelopment and risk for psychosis in epilepsy patients
Details
- Title: Subtitle
- Enlarged hippocampal fissure in psychosis of epilepsy
- Creators
- James Allebone - Florey Institute of Neuroscience and Mental HealthRichard A. Kanaan - Austin HealthJerome J. Maller - Monash Alfred Psychiatry Research centreTerrence O'Brien - The Royal Melbourne HospitalSaul Mullen - Austin HealthMark Cook - St Vincent's Hospital MelbourneSophie Adams - The Royal Melbourne HospitalSimon Vogrin - St Vincent's Hospital MelbourneDavid Vaughan - Austin HealthAlan Connelly - Austin HealthPatrick Kwan - The Royal Melbourne HospitalSamuel F. Berkovic - Austin HealthWendyl D'Souza - St Vincent's Hospital Melbourne, AustraliaGraeme Jackson - Austin HealthDennis Velakoulis - The Royal Melbourne HospitalSarah J. Wilson - Austin Health
- Resource Type
- Journal article
- Publication Details
- Epilepsy & behavior, Vol.111, p.107290
- DOI
- 10.1016/j.yebeh.2020.107290
- PMID
- 32759068
- NLM abbreviation
- Epilepsy Behav
- ISSN
- 1525-5050
- eISSN
- 1525-5069
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 10/2020
- Academic Unit
- Radiology
- Record Identifier
- 9984848504002771
Metrics
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