Enriching the diet with menhaden oil improves peripheral neuropathy in streptozotocin-induced type 1 diabetic rats

Lawrence J Coppey; Eric P Davidson; Alexander Obrosov; Mark A Yorek

doi:10.1152/jn.00718.2014

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Enriching the diet with menhaden oil improves peripheral neuropathy in streptozotocin-induced type 1 diabetic rats

Journal article

Open access

Peer reviewed

Enriching the diet with menhaden oil improves peripheral neuropathy in streptozotocin-induced type 1 diabetic rats

Lawrence J Coppey, Eric P Davidson, Alexander Obrosov and Mark A Yorek

Journal of neurophysiology, Vol.113(3), pp.701-708

02/01/2015

DOI: 10.1152/jn.00718.2014

PMCID: PMC4312862

PMID: 25376787

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https://europepmc.org/articles/pmc4312862View

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Abstract

The purpose of this study was to determine the effect of supplementing the diet of type 1 diabetic rats with menhaden oil on diabetic neuropathy. Menhaden oil is a natural source for n-3 fatty acids, which have been shown to have beneficial effects in cardiovascular disease and other morbidities. Streptozotocin-induced diabetic rats were used to examine the influence of supplementing their diet with 25% menhaden oil on diabetic neuropathy. Both prevention and intervention protocols were used. Endpoints included motor and sensory nerve conduction velocity, thermal and mechanical sensitivity, and innervation and sensitivity of the cornea and hindpaw. Diabetic neuropathy as evaluated by the stated endpoints was found to be progressive. Menhaden oil did not improve elevated HbA1C levels or serum lipid levels. Diabetic rats at 16-wk duration were thermal hypoalgesic and had reduced motor and sensory nerve conduction velocities, and innervation and sensitivity of the cornea and skin were impaired. These endpoints were significantly improved with menhaden oil treatment following the prevention or intervention protocol. We found that supplementing the diet of type 1 diabetic rats with menhaden oil improved a variety of endpoints associated with diabetic neuropathy. These results suggest that enriching the diet with n-3 fatty acids may be a good treatment strategy for diabetic neuropathy.

Animals

Diabetes Mellitus, Experimental - complications

Diabetes Mellitus, Experimental - drug therapy

Diabetic Neuropathies - drug therapy

Dietary Supplements

Fish Oils - administration & dosage

Fish Oils - pharmacology

Fish Oils - therapeutic use

Glycated Hemoglobin A - metabolism

Hot Temperature

Hypesthesia - drug therapy

Lipids - blood

Male

Peripheral Nerves - drug effects

Peripheral Nerves - physiopathology

Rats

Rats, Sprague-Dawley

Touch

Details

Title: Subtitle: Enriching the diet with menhaden oil improves peripheral neuropathy in streptozotocin-induced type 1 diabetic rats
Creators: Lawrence J Coppey - University of Iowa
Eric P Davidson - University of Iowa
Alexander Obrosov - University of Iowa
Mark A Yorek - United States Department of Veterans Affairs
Resource Type: Journal article
Publication Details: Journal of neurophysiology, Vol.113(3), pp.701-708
DOI: 10.1152/jn.00718.2014
PMID: 25376787
PMCID: PMC4312862
ISSN: 0022-3077
eISSN: 1522-1598
Grant note: DK081147 / NIDDK NIH HHS I01 RX000889 / RRD VA
Language: English
Date published: 02/01/2015
Academic Unit: Fraternal Order of Eagles Diabetes Research Center; Endocrinology and Metabolism; Internal Medicine
Record Identifier: 9984359779502771

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27 Times Cited - Web of Science

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