Journal article
Enthesitis-related arthritis is associated with higher pain intensity and poorer health status in comparison with other categories of juvenile idiopathic arthritis: the Childhood Arthritis and Rheumatology Research Alliance Registry
Journal of rheumatology, Vol.39(12), pp.2341-2351
12/2012
DOI: 10.3899/jrheum.120642
PMCID: PMC3513507
PMID: 23070991
Abstract
To assess the relative effect of clinical factors and medications on pain intensity, physical function, and health status in juvenile idiopathic arthritis (JIA).
We conducted a retrospective cross-sectional study of data from children with JIA enrolled in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry. We tested whether clinical characteristics of JIA were associated with pain intensity, physical function, and health status using multivariable linear and ordinal logistic regression.
During the study period, 2571 subjects with JIA enrolled in the CARRA Registry. Ratings of pain intensity, physical function, and health status differed significantly between JIA categories. In comparison to other categories of JIA, subjects with enthesitis-related arthritis (ERA) reported worse pain and function. In multivariable analyses, higher active joint count and current use of nonsteroidal antiinflammatory drugs (NSAID), biologics, or corticosteroids were associated with worse scores on all patient-reported measures. ERA and older age were significantly associated with higher pain intensity and poorer health status. Systemic JIA and uveitis were significantly associated with worse health status. Enthesitis, sacroiliac tenderness, and NSAID use were independently associated with increased pain intensity in ERA. The correlation was low between physician global assessment of disease activity and patient-reported pain intensity, physical function, and health status.
Significant differences in pain intensity, physical function, and health status exist among JIA categories. These results suggest that current treatments may not be equally effective for particular disease characteristics more common in specific JIA categories, such as enthesitis or sacroiliac tenderness in ERA.
Details
- Title: Subtitle
- Enthesitis-related arthritis is associated with higher pain intensity and poorer health status in comparison with other categories of juvenile idiopathic arthritis: the Childhood Arthritis and Rheumatology Research Alliance Registry
- Creators
- Pamela F Weiss - Department of Pediatrics, University of Pennsylvania, Philadelphia, PA, USA. weisspa@email.chop.eduTimothy BeukelmanLaura E SchanbergYukiko KimuraRobert A ColbertCARRA Registry
- Contributors
- Polly J Ferguson (Contributor) - University of Iowa, Stead Family Department of Pediatrics
- Resource Type
- Journal article
- Publication Details
- Journal of rheumatology, Vol.39(12), pp.2341-2351
- Publisher
- Canada
- DOI
- 10.3899/jrheum.120642
- PMID
- 23070991
- PMCID
- PMC3513507
- ISSN
- 0315-162X
- eISSN
- 1499-2752
- Grant note
- R01 AR053845 / NIAMS NIH HHS Intramural NIH HHS 1-K23-AR059749-01 / NIAMS NIH HHS K23 AR059749 / NIAMS NIH HHS AR053845 / NIAMS NIH HHS RC2AR058934 / NIAMS NIH HHS RC2 AR058934 / NIAMS NIH HHS
- Language
- English
- Date published
- 12/2012
- Academic Unit
- Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Rheumatology, Allergy, and Immunology
- Record Identifier
- 9984065840402771
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