Journal article
Environmental Nickel Exposure and Diabetes in a Nationally Representative Sample of US Adults
Exposure and health, Vol.13(4), pp.697-704
09/29/2021
DOI: 10.1007/s12403-021-00413-9
PMCID: PMC9175810
PMID: 35685677
Abstract
Laboratory studies have shown that nickel exposure may adversely affect glucose metabolism. However, studies about the effects of environmental nickel exposure on diabetes pathogenesis in humans are sparse. We aimed to evaluate the association of urinary nickel concentrations, as a biomarker of environmental nickel exposure, and diabetes in a nationally representative sample of US adults. The data from a nationally representative population (n = 1585) in the National Health and Nutrition Examination Survey 2017–18 were used. Diabetes (
n
= 330) was defined as self-reported physician’s diagnosis, HbA1c ≥ 6.5%, fasting plasma glucose ≥ 126 mg/dL, or 2-h plasma glucose ≥ 200 mg/dL. Urinary nickel concentrations were determined by inductively coupled plasma mass spectrometry. Logistic regression with sample weights was used to estimate the odds ratios (ORs) of diabetes and 95% confidence intervals (CIs). Urinary nickel concentrations were higher in individuals with diabetes (weighted median 1.23 μg/L) than those without diabetes (1.01 μg/L). After adjustment for urinary creatinine and other risk factors for diabetes, the OR of diabetes comparing the highest with lowest quartile of urinary nickel concentrations was 2.70 (95% CI 1.39–5.24; P
trend
= 0.03). Environmental nickel exposure is positively and significantly associated with diabetes in U.S. adults.
Details
- Title: Subtitle
- Environmental Nickel Exposure and Diabetes in a Nationally Representative Sample of US Adults
- Creators
- Tyler J Titcomb - Department of Epidemiology, College of Public Health, University of Iowa, Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Fraternal Order of Eagles Diabetes Research Center, University of IowaBuyun Liu - Department of Epidemiology, College of Public Health, University of IowaHans‐Joachim Lehmler - Department of Occupational and Environmental Health, College of Public Health, University of Iowa, Environmental Health Sciences Research Center, University of IowaLinda G Snetselaar - Department of Epidemiology, College of Public Health, University of Iowa, Fraternal Order of Eagles Diabetes Research Center, University of IowaWei Bao - Department of Epidemiology, College of Public Health, University of Iowa, Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Environmental Health Sciences Research Center, University of Iowa
- Resource Type
- Journal article
- Publication Details
- Exposure and health, Vol.13(4), pp.697-704
- DOI
- 10.1007/s12403-021-00413-9
- PMID
- 35685677
- PMCID
- PMC9175810
- NLM abbreviation
- Expo Health
- ISSN
- 2451-9766
- eISSN
- 2451-9685
- Publisher
- Springer Netherlands
- Grant note
- T32DK112751-01 / National Institute of Diabetes and Digestive and Kidney Diseases (http://dx.doi.org/10.13039/100000062) P30 ES005605 / National Institutes of Health (http://dx.doi.org/10.13039/100000002) R21 HD091458 / National Institute of Child Health and Human Development (http://dx.doi.org/10.13039/100000071)
- Language
- English
- Date published
- 09/29/2021
- Academic Unit
- Occupational and Environmental Health; Epidemiology; Iowa Neuroscience Institute; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9984215147602771
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