Environmental and dietary risk factors for infantile atopic eczema among a Slovak birth cohort

Anne L Dunlop; Eva Reichrtova; Luba Palcovicova; Peter Ciznar; Andrea Adamcakova-Dodd; S J Smith; Scott J N McNabb

doi:10.1111/j.1399-3038.2005.00372.x

Back

Environmental and dietary risk factors for infantile atopic eczema among a Slovak birth cohort

Journal article

Peer reviewed

Environmental and dietary risk factors for infantile atopic eczema among a Slovak birth cohort

Anne L Dunlop, Eva Reichrtova, Luba Palcovicova, Peter Ciznar, Andrea Adamcakova-Dodd, S J Smith and Scott J N McNabb

Pediatric allergy and immunology, Vol.17(2), pp.103-111

03/2006

DOI: 10.1111/j.1399-3038.2005.00372.x

PMID: 16618359

View Online

Abstract

Infantile atopic eczema (AE) is a risk marker for future asthma. This study assesses the contribution of modifiable exposures to infantile AE. If modifiable exposures contribute substantially to infantile AE, its prevention might be a sensible approach to asthma prevention. Pregnant women (n = 1978) were systematically recruited from maternity hospitals of the Slovak Republic; their birthed cohort of 1990 children were prospectively followed for 1 yr. Children's exposures to selected environmental and dietary factors were assessed via maternal questionnaires administered at delivery and 1 yr of age. A child was considered to have AE, based on physical examination (SCORAD index >2) or mother's report of a previous physician diagnosis. Multivariate logistic regression was used to calculate adjusted odds ratios and percent total regression scores (TRS) for each variable. At 1 yr of age 1326 (67%) of the children remained in the cohort and 207 (15.6%) developed AE. Various modifiable environmental and dietary exposures increased the likelihood of AE (ownership of cats; consumption of infant formula, eggs, and fish) while others decreased the likelihood of AE (ownership of livestock; exclusive breast feeding for > or =4 months). Overall, modifiable exposures contributed less to the TRS than did non-modifiable exposures (38% vs. 62%, respectively). The modifiable exposure category that contributed most to the TRS was infant feeding practices (27.5% TRS). Modifiable exposures -- especially those related to infant feeding practices -- significantly contribute to infantile AE, although modifiable factors contribute less overall than do non-modifiable exposures.

Adult

Asthma - prevention & control

Cohort Studies

Dermatitis, Atopic - epidemiology

Dermatitis, Atopic - etiology

Dermatitis, Atopic - prevention & control

Diet - adverse effects

Environmental Exposure - adverse effects

Female

Humans

Infant

Logistic Models

Male

Multivariate Analysis

Pregnancy

Prevalence

Prospective Studies

Risk Factors

Slovakia

Details

Title: Subtitle: Environmental and dietary risk factors for infantile atopic eczema among a Slovak birth cohort
Creators: Anne L Dunlop - Emory University
Eva Reichrtova - Slovak Medical University
Luba Palcovicova - Slovak Medical University
Peter Ciznar
Andrea Adamcakova-Dodd - University of Iowa
S J Smith - Centers for Disease Control and Prevention
Scott J N McNabb - Centers for Disease Control and Prevention
Resource Type: Journal article
Publication Details: Pediatric allergy and immunology, Vol.17(2), pp.103-111
DOI: 10.1111/j.1399-3038.2005.00372.x
PMID: 16618359
ISSN: 0905-6157
eISSN: 1399-3038
Language: English
Date published: 03/2006
Academic Unit: Occupational and Environmental Health
Record Identifier: 9985239182502771

Metrics

1 Record Views

22 Times Cited - Web of Science