Environmental designer drugs: when transformation may not eliminate risk

David M Cwiertny; Shane A Snyder; Daniel Schlenk; Edward P Kolodziej

doi:10.1021/es503425w

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Environmental designer drugs: when transformation may not eliminate risk

Journal article

Open access

Peer reviewed

Environmental designer drugs: when transformation may not eliminate risk

David M Cwiertny, Shane A Snyder, Daniel Schlenk and Edward P Kolodziej

Environmental science & technology, Vol.48(20), pp.11737-11745

10/21/2014

DOI: 10.1021/es503425w

PMCID: PMC4204896

PMID: 25216024

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Abstract

Environmental transformation processes, including those occurring in natural and engineered systems, do not necessarily drastically alter molecular structures of bioactive organic contaminants. While the majority of generated transformation products are likely benign, substantial conservation of structure in transformation products can imply conservation or even creation of bioactivity across multiple biological end points and thus incomplete mitigation of ecological risk. Therefore, focusing solely on parent compound removal for contaminants of higher relative risk, the most common approach to fate characterization, provides no mechanistic relationship to potential biological effects and is inadequate as a comprehensive metric for reduction of ecological risks. Here, we explore these phenomena for endocrine-active steroid hormones, focusing on examples of conserved bioactivity and related implications for fate assessment, regulatory approaches, and research opportunities.

Designer Drugs - chemistry

Environment

Risk

Designer Drugs - metabolism

Details

Title: Subtitle: Environmental designer drugs: when transformation may not eliminate risk
Creators: David M Cwiertny - Civil and Environmental Engineering, University of Iowa , 4105 Seamans Center, Iowa City, Iowa 52242, United States
Shane A Snyder
Daniel Schlenk
Edward P Kolodziej
Resource Type: Journal article
Publication Details: Environmental science & technology, Vol.48(20), pp.11737-11745
DOI: 10.1021/es503425w
PMID: 25216024
PMCID: PMC4204896
NLM abbreviation: Environ Sci Technol
ISSN: 1520-5851
eISSN: 1520-5851
Publisher: United States
Grant note: P30 ES005605 / NIEHS NIH HHS P30 ES06694 / NIEHS NIH HHS P30 ES006694 / NIEHS NIH HHS
Language: English
Date published: 10/21/2014
Academic Unit: Center for Health Effects of Environmental Contamination; Civil and Environmental Engineering; Public Policy Center (Archive); Chemical and Biochemical Engineering
Record Identifier: 9983991992502771

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