Environmental risk factors and perinatal outcomes in preterm newborns, according to family recurrence of prematurity

Hugo B Krupitzki; Enrique C Gadow; Juan A Gili; Belén Comas; Viviana R Cosentino; César Saleme; Jeffrey C Murray; Jorge S Lopez Camelo

doi:10.1055/s-0032-1326990

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Environmental risk factors and perinatal outcomes in preterm newborns, according to family recurrence of prematurity

Journal article

Open access

Peer reviewed

Environmental risk factors and perinatal outcomes in preterm newborns, according to family recurrence of prematurity

Hugo B Krupitzki, Enrique C Gadow, Juan A Gili, Belén Comas, Viviana R Cosentino, César Saleme, Jeffrey C Murray and Jorge S Lopez Camelo

American journal of perinatology, Vol.30(6), pp.451-462

06/2013

DOI: 10.1055/s-0032-1326990

PMCID: PMC3974336

PMID: 23132119

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https://www.ncbi.nlm.nih.gov/pmc/articles/3974336View

Open Access

Abstract

We analyzed the role of environmental risk factors, sociodemographic characteristics, clinical characteristics, and reproductive history in preterm births and their associated perinatal outcomes in families classified according to their histories of preterm recurrence among siblings. A retrospective study was conducted at Nuestra Señora de la Merced Maternity Hospital in the city of Tucumán, Argentina. A total of 348 preterm, non-malformed, singleton children born to multipara women were reviewed. The family history score described by Khoury was applied, and families were classified as having no, medium, or high genetic aggregation. Families with no familial aggregation showed a higher rate of short length of cohabitation, maternal urinary tract infections during the current pregnancy, and maternal history of miscarriage during the previous pregnancy. Families with a high level of aggregation had a significantly higher incidence of pregnancy complications, such as diabetes, hypertension, and immunologic disorders. Reproductive histories clearly differed between the groups, suggesting both a different response to environmental challenges based on genetic susceptibility and the activation of different pathophysiological pathways to determine the duration of pregnancy in each woman.

Pregnancy

Recurrence

Life Style

Premature Birth - genetics

Humans

Risk Factors

Male

Fetal Membranes, Premature Rupture - epidemiology

Premature Birth - epidemiology

Abortion, Spontaneous - epidemiology

Premature Birth - physiopathology

Stillbirth - epidemiology

Female

Retrospective Studies

Infant, Newborn

Pregnancy Complications - epidemiology

Pregnancy Outcome

Cluster Analysis

Details

Title: Subtitle: Environmental risk factors and perinatal outcomes in preterm newborns, according to family recurrence of prematurity
Creators: Hugo B Krupitzki - Dirección de Investigación, CEMIC (Centro de Educación Médica e Investigaciones Clínicas), Buenos Aires, Argentina. hkrupitzki@cemic.edu.ar
Enrique C Gadow
Juan A Gili
Belén Comas
Viviana R Cosentino
César Saleme
Jeffrey C Murray
Jorge S Lopez Camelo
Resource Type: Journal article
Publication Details: American journal of perinatology, Vol.30(6), pp.451-462
DOI: 10.1055/s-0032-1326990
PMID: 23132119
PMCID: PMC3974336
NLM abbreviation: Am J Perinatol
ISSN: 0735-1631
eISSN: 1098-8785
Publisher: United States
Grant note: P30 ES005605 / NIEHS NIH HHS 1R01 HD-529 / NICHD NIH HHS R01 HD052953 / NICHD NIH HHS
Language: English
Date published: 06/2013
Academic Unit: Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Dental Research
Record Identifier: 9984025472402771

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