Journal article
Enzymatic aspects of the phenol (aryl) sulfotransferases
Drug metabolism reviews, Vol.33(3-4), pp.369-395
2001
DOI: 10.1081/DMR-120001394
PMID: 11768773
Abstract
The sulfotransferases that are active in the metabolism of xenobiotic represent a large family of enzymes that catalyze the transfer of the sulfuryl group from 3′-phosphoadenosine 5′-phosphosulfate to phenols, to primary and secondary alcohols, to several additional oxygen containing functional groups, and to amines. Restriction of this review to the catalytic processes of phenol or aryl sulfotransferases does not really narrow the field, because these enzymes have overlapping specificity, not only for specific compounds, but also for multiple functional groups. The presentation aims to provide an overview of the wealth of phenol sulfotransferases that are available for study but concentrates on the enzymology of rat and human enzymes, particularly on the predominant phenol sulfotransferase from rat liver. The kinetics and catalytic mechanism of the rat enzyme is extensively reviewed and is compared with observations from other sulfotransferases.
Details
- Title: Subtitle
- Enzymatic aspects of the phenol (aryl) sulfotransferases
- Creators
- Michael W Duffel - University of IowaA. David Marshall - National Institute of Diabetes and Digestive and Kidney DiseasesPeter Mcphie - National Institute of Diabetes and Digestive and Kidney DiseasesVyas Sharma - University of IowaWilliam B Jakoby - National Institute of Diabetes and Digestive and Kidney Diseases
- Resource Type
- Journal article
- Publication Details
- Drug metabolism reviews, Vol.33(3-4), pp.369-395
- Publisher
- Informa Healthcare
- DOI
- 10.1081/DMR-120001394
- PMID
- 11768773
- ISSN
- 0360-2532
- eISSN
- 1097-9883
- Language
- English
- Date published
- 2001
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics; Medicinal and Natural Products Chemistry
- Record Identifier
- 9984303287102771
Metrics
11 Record Views